抗菌药耐药性和传统抗生素的新型替代方法

Bacteria Pub Date : 2024-07-22 DOI:10.3390/bacteria3030012
Irene Berger, Z. Loewy
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引用次数: 0

摘要

抗菌药耐药性是一个重大的公共卫生问题。世界卫生组织已将抗生素耐药性的空前蔓延确定为医疗保健领域的主要威胁之一。据预测,到 2050 年,全球每年因抗菌药耐药性导致的死亡人数将接近 1000 万,相关经济负担将达到 100 万亿美元。本文回顾了导致抗菌药耐药性的已知机制,并深入探讨了传统抗生素的潜在替代品。本文探讨的抗菌方法包括双重抗生素疗法、抗菌肽、单克隆抗体、噬菌体、益生菌、纳米材料和大麻素。还讨论了需要抗菌剂的主要病原体,这些病原体被称为 ESKAPE 病原体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antimicrobial Resistance and Novel Alternative Approaches to Conventional Antibiotics
Antimicrobial resistance is a significant public health issue. The unprecedented spread of antimicrobial-resistant organisms has been identified by the World Health Organization as one of the leading healthcare threats. Projections for annual worldwide deaths attributed to antimicrobial resistance approach 10 million by 2050, with an associated economic burden of USD 100 trillion. This paper reviews the mechanisms known to contribute to antimicrobial resistance and provides insight into potential available alternatives to conventional antibiotics. Antimicrobial approaches addressed include dual antibiotic therapy, antimicrobial peptides, monoclonal antibodies, bacteriophages, probiotics, nanomaterials, and cannabinoids. Key pathogens in need of antimicrobials referred to as the ESKAPE pathogens are discussed.
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