基于 SEAr 烷基化的 4-(4-羟基苯基)环烷二羧酸合成方法

ЖУРНАЛ ОБЩЕЙ ХИМИИ Pub Date : 2024-07-23 DOI:10.31857/s0044460x24020015

A. A. Firstova, E. R. Kofanov, M. S. Biryukova, A. S. Lebedev

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引用次数: 0

摘要

对苯甲醚与环烷二羧酸在各种催化体系存在下的烷基化反应进行了研究。研究发现，在氯化铝、三氯化铁和对甲苯磺酸存在的情况下，反应的产率较高。研究还证明了进一步裂解醚键以获得 4-（4-羟基苯基）环烷二羧酸的可能性。由此产生的化合物具有潜在的生物活性。

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Method for Synthesis of 4-(4-Hydroxyphenyl)cycloalkanedicarboxylic Acids Based on SEAr Alkylation

A study was carried out on the alkylation reaction of anisole with cycloalkenedicarboxylic acids in the presence of various catalytic systems. It was found that the reaction proceeds with high yields in the presence of aluminum chloride, ferric chloride, and p-toluenesulfonic acid. The possibility of further cleavage of the ether bond to obtain 4-(4-hydroxyphenyl)cycloalkanedicarboxylic acids was demonstrated. The resulting compounds are potential biologically active compounds.

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