自闭症谱系障碍中海马神经发生的研究进展

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-23 DOI:10.1002/ped4.12440

Mengxiang Chen, Lanmin Guo, Qinghong Li, Shunbo Yang, Wei Li, Yanmei Lai, Zhihai Lv

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引用次数: 0

摘要

自闭症谱系障碍（ASD）是一组严重的神经发育障碍，病因不清，异质性很大，正在成为一个全球性的公共卫生问题。越来越多的研究表明，海马神经发生缺陷参与了自闭症谱系障碍的发病和发展，这引起了人们对自闭症谱系障碍中海马神经发生问题的日益关注。本文分析了国际上关于 ASD 中海马神经发生的相关研究，讨论了神经生物学在 ASD 发病机制中的作用，并探讨了改善海马神经发生作为 ASD 治疗方法的潜力。本综述旨在为临床实践提供新的治疗视角和理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research progress on hippocampal neurogenesis in autism spectrum disorder

Autism spectrum disorder (ASD) is a group of severe neurodevelopmental disorders with unclear etiology and significant heterogeneity that is emerging as a global public health concern. Increasing research suggests the involvement of hippocampal neurogenesis defects in the onset and development of ASD, drawing increasing amounts of attention to hippocampal neurogenesis issues in ASD. In this paper, we analyze relevant international studies on hippocampal neurogenesis in ASD, discuss the role of neurobiology in the pathogenesis of ASD, and explore the potential of improving hippocampal neurogenesis as a therapeutic approach for ASD. This review aims to provide new treatment perspectives and theoretical foundations for clinical practice.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.