高血压父母的怀孕后代与非高血压父母的怀孕后代的等长手握试验比较

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-26 DOI:10.4103/jfmpc.jfmpc_5_24

CS Siva Shankari, Aruna Raju, Uthpala Vadakaluru, S. Niveatha

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引用次数: 0

摘要

摘要高血压家族史是妊娠诱发高血压（PIH）的重要危险因素之一。高血压父母的后代应接受 PIH 筛查。等长握手（IHG）试验可用于评估他们的自主神经功能。自主神经功能失调可预示其在妊娠后期易患 PIH。比较高血压父母（第 1 组）和非高血压父母（第 2 组）的妊娠后代的 IHG。这是一项横断面研究，研究对象为 100 名怀孕后三个月的孕妇（每组 50 人）。分别在 IHG 测试结束后和 IHG 测试 5 分钟后记录持续握手 2 分钟最大自主收缩（MVC）时的血压反应。采用独立 t 检验和 Mann-Whitney U 检验比较两组的反应。两组的基础血压和心率没有统计学差异。IHG 试验 2 分钟后，第一组的收缩压（SBP）和舒张压（DBP）比第二组明显升高。IHG 5 分钟后，第 2 组的 SBP 明显升高。与血压正常的父母的后代相比，高血压父母的后代交感神经反应性增高，血压恢复能力明显降低，这可能使他们容易患 PIH。IHG 可作为一种方便的工具，用于筛查初级保健中心或实地筛查等场所的 PIH 高危人群，IHG 是其中一种可能的选择。

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Comparison of isometric handgrip test among pregnant offspring of hypertensive parents and pregnant offspring of non-hypertensive parents

ABSTRACT A family history of hypertension is one of the important risk factors for the development of pregnancy-induced hypertension (PIH). Offspring of hypertensive parents should be screened for PIH. The isometric handgrip (IHG) test is used to assess autonomic function among them. Autonomic function dysregulation can indicate their predisposition to develop PIH later in the course of pregnancy. To compare the IHG among pregnant offspring of hypertensive parents (Group 1) and non-hypertensive parents (Group 2). This is a cross-sectional study done among 100 pregnant women in the second trimester (50 participants in each group). Blood pressure responses to sustained hand grip for 2 minutes of maximum voluntary contraction (MVC) were recorded, immediately at the end of the IHG test and after 5 minutes of the IHG test. Independent t-test and Mann–Whitney U test were used to compare the responses in two groups. There is no statistical difference in basal blood pressure and heart rate between the two groups. Group 1 exhibited a significant increase in systolic blood pressure (SBP) and diastolic blood pressure (DBP) compared to Group 2 immediately after 2 minutes of the IHG test. There is a significant increase in SBP after 5 minutes of the IHG in Group 2. Offspring of hypertensive parents have increased sympathetic reactivity and restoration of the blood pressure is significantly less compared to offspring of normotensive parents, which may predispose them for PIH. IHG can be applied as a convenient tool to screen the population who are at risk of PIH in places like primary health centres or field screenings where IHG is one possible option.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.