{"title":"探索阿尔茨海默病与 COVID-19 的相互作用：认知障碍和药物相互作用的启示","authors":"Jiachen Xu","doi":"10.54254/2753-8818/44/20240471","DOIUrl":null,"url":null,"abstract":"Alzheimers disease (AD) is a severe well-known cognitive disease, and it is also the most worldwide cause of dementia. Studies have shown that AD may have some interactions with the coronavirus disease 2019 (COVID-19) in some particular areas. This paper aims to figure out the potential associations how one causes the interplay of another, whether directly or indirectly. In addition, the paper provides a comprehensive mechanism underlying cognitive impairment also known as brain fog of COVID-19, including the effects on neurons and glial cells by persistent elevation of the chemokine CCL11. Then the paper provides drug-drug interaction with metabolized by same cytochrome enzymes lead to major changes in the pharmacology of treatments. Finally, the paper concludes the points mentioned about the associations between COVID-19 and AD then suggests the direction of the future studies.","PeriodicalId":341023,"journal":{"name":"Theoretical and Natural Science","volume":"55 7","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the interplay between Alzheimer's disease and COVID-19: Insights into cognitive impairment and drug interactions\",\"authors\":\"Jiachen Xu\",\"doi\":\"10.54254/2753-8818/44/20240471\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Alzheimers disease (AD) is a severe well-known cognitive disease, and it is also the most worldwide cause of dementia. Studies have shown that AD may have some interactions with the coronavirus disease 2019 (COVID-19) in some particular areas. This paper aims to figure out the potential associations how one causes the interplay of another, whether directly or indirectly. In addition, the paper provides a comprehensive mechanism underlying cognitive impairment also known as brain fog of COVID-19, including the effects on neurons and glial cells by persistent elevation of the chemokine CCL11. Then the paper provides drug-drug interaction with metabolized by same cytochrome enzymes lead to major changes in the pharmacology of treatments. Finally, the paper concludes the points mentioned about the associations between COVID-19 and AD then suggests the direction of the future studies.\",\"PeriodicalId\":341023,\"journal\":{\"name\":\"Theoretical and Natural Science\",\"volume\":\"55 7\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Theoretical and Natural Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54254/2753-8818/44/20240471\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Theoretical and Natural Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54254/2753-8818/44/20240471","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Exploring the interplay between Alzheimer's disease and COVID-19: Insights into cognitive impairment and drug interactions
Alzheimers disease (AD) is a severe well-known cognitive disease, and it is also the most worldwide cause of dementia. Studies have shown that AD may have some interactions with the coronavirus disease 2019 (COVID-19) in some particular areas. This paper aims to figure out the potential associations how one causes the interplay of another, whether directly or indirectly. In addition, the paper provides a comprehensive mechanism underlying cognitive impairment also known as brain fog of COVID-19, including the effects on neurons and glial cells by persistent elevation of the chemokine CCL11. Then the paper provides drug-drug interaction with metabolized by same cytochrome enzymes lead to major changes in the pharmacology of treatments. Finally, the paper concludes the points mentioned about the associations between COVID-19 and AD then suggests the direction of the future studies.
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