Ting Bai, Yuemei Han, Chen Qin, Di Hu, Quankui Lin
{"title":"光交联水凝胶作为白内障手术植入的可注射眼内透镜","authors":"Ting Bai, Yuemei Han, Chen Qin, Di Hu, Quankui Lin","doi":"10.1177/08839115241262036","DOIUrl":null,"url":null,"abstract":"Cataract is the leading cause of the blindness worldwide. Natural lens removal followed with intraocular lens (IOL) implantation is the main clinical treatment for cataract. However, the shape and the optical power of current IOLs were fixed, which were not favorable for patients, especially for children with congenital cataracts. An injectable IOL is an immerging replacement for a regular IOL due to the accommodation of external packing shapes. In this study, we developed a rapid, in situ gelation of an injectable photo-crosslinked hydrogel as an injectable IOL material. In this investigation, injectable hydrogel (G/D hydrogel) was fabricated from Gelatin methacrylate (GelMA) and N- (3, 4-dihydroxyphenylidene ethyl) methacrylamide (DMA) via photo-crosslinking for injectable IOL applications. Different preparation parameters such as the concentration, proportion, light intensity, and curing time were optimized based on the gelation time, swelling ratio, and mechanical properties of the produced G/D hydrogels. The results of in vitro cellular experiments showed that the G/D hydrogel had good and stable clearance of lens epithelial cells. The hydrogel was implanted into the eyes of the young rabbits for 1 month, and the results also showed that injectable G/D hydrogel can obtain good intraocular implants and have inhibitory effects on posterior capsular opacification. Thus such photo-crosslinked G/D hydrogel can serve as an injectable IOL application in cataract surgery.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Photo-crosslinked hydrogel as injectable intraocular lens for cataract surgery implantation\",\"authors\":\"Ting Bai, Yuemei Han, Chen Qin, Di Hu, Quankui Lin\",\"doi\":\"10.1177/08839115241262036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cataract is the leading cause of the blindness worldwide. Natural lens removal followed with intraocular lens (IOL) implantation is the main clinical treatment for cataract. However, the shape and the optical power of current IOLs were fixed, which were not favorable for patients, especially for children with congenital cataracts. An injectable IOL is an immerging replacement for a regular IOL due to the accommodation of external packing shapes. In this study, we developed a rapid, in situ gelation of an injectable photo-crosslinked hydrogel as an injectable IOL material. In this investigation, injectable hydrogel (G/D hydrogel) was fabricated from Gelatin methacrylate (GelMA) and N- (3, 4-dihydroxyphenylidene ethyl) methacrylamide (DMA) via photo-crosslinking for injectable IOL applications. Different preparation parameters such as the concentration, proportion, light intensity, and curing time were optimized based on the gelation time, swelling ratio, and mechanical properties of the produced G/D hydrogels. The results of in vitro cellular experiments showed that the G/D hydrogel had good and stable clearance of lens epithelial cells. The hydrogel was implanted into the eyes of the young rabbits for 1 month, and the results also showed that injectable G/D hydrogel can obtain good intraocular implants and have inhibitory effects on posterior capsular opacification. Thus such photo-crosslinked G/D hydrogel can serve as an injectable IOL application in cataract surgery.\",\"PeriodicalId\":15038,\"journal\":{\"name\":\"Journal of Bioactive and Compatible Polymers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-07-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Bioactive and Compatible Polymers\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1177/08839115241262036\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bioactive and Compatible Polymers","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/08839115241262036","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Photo-crosslinked hydrogel as injectable intraocular lens for cataract surgery implantation
Cataract is the leading cause of the blindness worldwide. Natural lens removal followed with intraocular lens (IOL) implantation is the main clinical treatment for cataract. However, the shape and the optical power of current IOLs were fixed, which were not favorable for patients, especially for children with congenital cataracts. An injectable IOL is an immerging replacement for a regular IOL due to the accommodation of external packing shapes. In this study, we developed a rapid, in situ gelation of an injectable photo-crosslinked hydrogel as an injectable IOL material. In this investigation, injectable hydrogel (G/D hydrogel) was fabricated from Gelatin methacrylate (GelMA) and N- (3, 4-dihydroxyphenylidene ethyl) methacrylamide (DMA) via photo-crosslinking for injectable IOL applications. Different preparation parameters such as the concentration, proportion, light intensity, and curing time were optimized based on the gelation time, swelling ratio, and mechanical properties of the produced G/D hydrogels. The results of in vitro cellular experiments showed that the G/D hydrogel had good and stable clearance of lens epithelial cells. The hydrogel was implanted into the eyes of the young rabbits for 1 month, and the results also showed that injectable G/D hydrogel can obtain good intraocular implants and have inhibitory effects on posterior capsular opacification. Thus such photo-crosslinked G/D hydrogel can serve as an injectable IOL application in cataract surgery.
期刊介绍:
The use and importance of biomedical polymers, especially in pharmacology, is growing rapidly. The Journal of Bioactive and Compatible Polymers is a fully peer-reviewed scholarly journal that provides biomedical polymer scientists and researchers with new information on important advances in this field. Examples of specific areas of interest to the journal include: polymeric drugs and drug design; polymeric functionalization and structures related to biological activity or compatibility; natural polymer modification to achieve specific biological activity or compatibility; enzyme modelling by polymers; membranes for biological use; liposome stabilization and cell modeling. This journal is a member of the Committee on Publication Ethics (COPE).