用于消融引起的坏死病灶可视化的心脏门控光谱光声成像。

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
Shang Gao, Hiroshi Ashikaga, Masahito Suzuki, Tommaso Mansi, Young-Ho Kim, Florin-Cristian Ghesu, Jeeun Kang, Emad M. Boctor, Henry R. Halperin, Haichong K. Zhang
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引用次数: 0

摘要

射频消融术是治疗心房颤动的一种微创疗法。传统的射频手术缺乏对消融引起的坏死的术中监测,从而使完整性评估变得复杂。虽然光谱光声(sPA)成像有望区分消融组织,但由于运动导致成像质量低,多光谱成像在体内具有挑战性。在这里,我们引入了心脏门控 sPA 成像(CG-sPA)框架,利用运动门控平均滤波器,依靠图像相似性提高图像质量。坏死范围是根据光谱未混合消融组织对比度与总组织对比度之间的比率计算得出的,并以连续彩色图的形式显示,以突出坏死区域。在体内外猪模型中对这一概念进行了验证。通过 CG-sPA 成像,在整个心脏周期中都能成功检测到消融引起的坏死病灶。结果表明,CG-sPA 成像框架很有可能被纳入临床工作流程,为术中消融手术提供指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cardiac-gated spectroscopic photoacoustic imaging for ablation-induced necrotic lesion visualization

Cardiac-gated spectroscopic photoacoustic imaging for ablation-induced necrotic lesion visualization

Radiofrequency (RF) ablation is a minimally invasive therapy for atrial fibrillation. Conventional RF procedures lack intraoperative monitoring of ablation-induced necrosis, complicating assessment of completeness. While spectroscopic photoacoustic (sPA) imaging shows promise in distinguishing ablated tissue, multi-spectral imaging is challenging in vivo due to low imaging quality caused by motion. Here, we introduce a cardiac-gated sPA imaging (CG-sPA) framework to enhance image quality using a motion-gated averaging filter, relying on image similarity. Necrotic extent was calculated based on the ratio between spectral unmixed ablated tissue contrast and total tissue contrast, visualizing as a continuous color map to highlight necrotic area. The validation of the concept was conducted in both ex vivo and in vivo swine models. The ablation-induced necrotic lesion was successfully detected throughout the cardiac cycle through CG-sPA imaging. The results suggest the CG-sPA imaging framework has great potential to be incorporated into clinical workflow to guide ablation procedures intraoperatively.

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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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