特征向量中心性图谱揭示了抗NMDA受体脑炎中大脑功能动态的波动性。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Pub Date : 2024-11-01 DOI:10.1016/j.bpsc.2024.07.021

Tim J. Hartung , Nina von Schwanenflug , Stephan Krohn , Tommy A.A. Broeders , Harald Prüss , Menno M. Schoonheim , Carsten Finke

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引用次数: 0

摘要

背景：抗N-甲基-D-天冬氨酸受体脑炎（NMDARE）会导致与功能连接性改变相关的长期认知障碍。特征向量中心性（EC）绘图是一种功能强大的新方法，可通过数据驱动的体素和时间分辨来估计网络的重要性--超越了经典的 "静态 "功能连通性的变化：为了评估大脑功能网络组织的变化，我们对 73 名 NMDARE 患者和 73 名匹配的健康对照者进行了 EC 映射。结果：动态、时间分辨 EC 显示，海马区和皮质脑区之间的同步性与认知和临床参数相关：动态、时间分辨EC在13个皮质区域显示出明显较高的变异性（p(FWE)(FWE)(max)=3.76），并与患者的言语外显记忆相关（r=0.28，p=0.019）。静态EC分析显示，只有一个脑区（左侧钙内皮层）存在群体差异：网络动态的广泛变化和海马-内侧前额叶同步性的降低与言语表观记忆缺陷有关，因此可能代表了 NMDARE 认知功能障碍的功能神经相关性。重要的是，与传统的静态方法相比，动态EC检测到的网络改变要多得多，这凸显了这种方法在解释NMDARE长期缺陷方面的潜力。

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Eigenvector Centrality Mapping Reveals Volatility of Functional Brain Dynamics in Anti-NMDA Receptor Encephalitis

Background

Anti-NMDA receptor encephalitis (NMDARE) causes long-lasting cognitive deficits associated with altered functional connectivity. Eigenvector centrality (EC) mapping represents a powerful new method for data-driven voxelwise and time-resolved estimation of network importance—beyond changes in classical static functional connectivity.

Methods

To assess changes in functional brain network organization, we applied EC mapping in 73 patients with NMDARE and 73 matched healthy control participants. Areas with significant group differences were further investigated using 1) spatial clustering analyses, 2) time series correlation to assess synchronicity between the hippocampus and cortical brain regions, and 3) correlation with cognitive and clinical parameters.

Results

Dynamic, time-resolved EC showed significantly higher variability in 13 cortical areas (familywise error p < .05) in patients with NMDARE compared with healthy control participants. Areas with dynamic EC group differences were spatially organized in centrality clusters resembling resting-state networks. Importantly, variability of dynamic EC in the frontotemporal cluster was associated with impaired verbal episodic memory in patients (r = −0.25, p = .037). EC synchronicity between the hippocampus and the medial prefrontal cortex was reduced in patients compared with healthy control participants (familywise error p < .05, t_max = 3.76) and associated with verbal episodic memory in patients (r = 0.28, p = .019). Static EC analyses showed group differences in only one brain region (left intracalcarine cortex).

Conclusions

Widespread changes in network dynamics and reduced hippocampal-medial prefrontal synchronicity were associated with verbal episodic memory deficits and may thus represent a functional neural correlate of cognitive dysfunction in NMDARE. Importantly, dynamic EC detected substantially more network alterations than traditional static approaches, highlighting the potential of this method to explain long-term deficits in NMDARE.

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来源期刊

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Neuroscience-Biological Psychiatry

CiteScore

10.40

自引率

1.70%

发文量

247

审稿时长

30 days

期刊介绍： Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.