活动性多发性硬化病灶的非对比磁共振评估:定量合成磁共振成像的新作用。

IF 1.3 Q4 NEUROIMAGING
Neuroradiology Journal Pub Date : 2025-04-01 Epub Date: 2024-07-29 DOI:10.1177/19714009241269541
Sachin Girdhar, Sruthi S Nair, Bejoy Thomas, Chandrasekharan Kesavadas
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引用次数: 0

摘要

目的:本研究旨在探索新型合成 MRI 衍生定量参数(包括髓鞘相关容积 (MyC))在不注射钆对比剂的情况下识别活动性 MS 病灶的实用性。多发性硬化斑块分为增强型(C)和非增强型(N)病变。根据病变的位置还可分为脑室周围 WM 病变 (P)、深部 WM 病变 (D)、幕下病变 (I) 和皮质-下皮质病变 (C)。在 MS 病变的合成 FLAIR 图像上放置 ROI,并获得 R1、R2、PD 和髓鞘相关体积(MyC)的定量参数。通过进行 ROC 曲线分析和逻辑回归分析,计算了区分增强型和非增强型多发性硬化病变的不同临界值的敏感性和特异性:与非增强病变相比,对比增强病变的平均 R1、R2 值明显较高,平均 PD 值较低 (p < 0.05),但特异性有限。区域分析显示,皮质-下皮质病变的平均 R1 和 R2 的 AUC 值较高(p < 0.001),其次是脑室周围病变(p < 0.003),可用于区分增强和非增强病变,而 MyC 和 PD 值的贡献不大:综合磁共振成像得出的平均R1、R2、MyC和PD定量参数在不使用钆类造影剂的情况下区分造影剂增强和非增强型多发性硬化病灶方面具有价值。然而,目前的研究并没有达到明显的特异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-contrast magnetic resonance evaluation of active multiple sclerosis lesions: Emerging role of quantitative synthetic magnetic resonance imaging.

PurposeThe current study aims to explore the utility of novel synthetic MRI-derived quantitative parameters including myelin-correlated volume (MyC) in identifying active MS lesions without injecting gadolinium contrast.Methods43 MS patients underwent institutional MS protocol including 3D FLAIR and post-contrast 3D T1VIBE sequence on a 1.5 T MR Scanner in addition to synthetic MRI sequence. MS plaques were categorised into enhancing (C) and non-enhancing (N) lesions. They were also sub-categorised based on location into periventricular WM lesions (P), deep WM lesions (D), infratentorial lesions (I) and cortical-juxtacortical (C) lesions. ROIs were placed on Synthetic FLAIR images in MS lesions and quantitative parameters of R1, R2, PD and myelin-correlated volume (MyC) obtained. Sensitivity and specificity for various cut-off values to differentiate enhancing from non-enhancing multiple sclerosis lesions were calculated by performing ROC curve analysis and logistic regression analysis.ResultsContrast enhancing lesions demonstrated significantly higher mean R1, R2 values and lower mean PD values in comparison to non-enhancing lesions (p < 0.05) but with limited specificity. Region-wise analysis revealed high AUC values for mean R1 and R2 at cortical-juxtacortical lesions (p < 0.001) followed by periventricular lesions (p < 0.003) for differentiating enhancing from non-enhancing lesions with no significant contribution from MyC and PD values.ConclusionSynthetic MRI-derived quantitative parameters of mean R1, R2, MyC and PD hold value in differentiating contrast enhancing and non-enhancing MS lesions without administering gadolinium-based contrast agent. However, the current study did not achieve significant specificity for establishing the same.

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来源期刊
Neuroradiology Journal
Neuroradiology Journal NEUROIMAGING-
CiteScore
2.50
自引率
0.00%
发文量
101
期刊介绍: NRJ - The Neuroradiology Journal (formerly Rivista di Neuroradiologia) is the official journal of the Italian Association of Neuroradiology and of the several Scientific Societies from all over the world. Founded in 1988 as Rivista di Neuroradiologia, of June 2006 evolved in NRJ - The Neuroradiology Journal. It is published bimonthly.
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