儿童接种 BNT162b2 疫苗 1 年后检测到非炎症性 SARS-CoV-2 穗状特异性 IgG4 抗体的延迟诱导。

IF 2.9 4区医学 Q3 IMMUNOLOGY

Pediatric Infectious Disease Journal Pub Date : 2024-07-30 DOI:10.1097/INF.0000000000004488

Robin Kobbe, Cornelius Rau, Ulf Schulze-Sturm, Felix Stahl, Luis Fonseca-Brito, Anke Diemert, Marc Lütgehetmann, Marylyn M Addo, Petra Arck, Leonie M Weskamm

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引用次数: 0

摘要

接种 BNT162b2 疫苗后的体液免疫反应主要由免疫球蛋白 (Ig) G1 和 IgG3 亚类抗体组成。正如之前在成人中描述的那样，5-11 岁儿童接种第二次 BNT162b2 疫苗 1 年后，S1 特异性和受体结合域特异性 IgG4 水平会显著增加。了解所有年龄组的 mRNA 疫苗特异性 IgG4 反应至关重要，因为未来几年将有更多的 mRNA 疫苗获得许可。

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Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies Detected 1 Year After BNT162b2 Vaccination in Children.

Humoral immune responses after BNT162b2 vaccination are predominantly composed of immunoglobulin (Ig) G1 and IgG3 subclass antibodies. As previously described in adults, S1-specific and receptor-binding domain-specific IgG4 levels increase significantly 1 year after the second BNT162b2 vaccination in children 5-11 years of age. Understanding mRNA vaccine-specific IgG4 responses in all age groups is crucial as more mRNA vaccines will reach licensure in the coming years.

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来源期刊

Pediatric Infectious Disease Journal 医学-传染病学

CiteScore

6.30

自引率

2.80%

发文量

566

审稿时长

2-4 weeks

期刊介绍： The Pediatric Infectious Disease Journal® (PIDJ) is a complete, up-to-the-minute resource on infectious diseases in children. Through a mix of original studies, informative review articles, and unique case reports, PIDJ delivers the latest insights on combating disease in children — from state-of-the-art diagnostic techniques to the most effective drug therapies and other treatment protocols. It is a resource that can improve patient care and stimulate your personal research.