I-III 期非小细胞肺癌患者常规临床实践中放疗方案的合规性。

IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Xiaoshui Huang, Matthew Field, Shalini Vinod, Helen Ball, Vikneswary Batumalai, Paul Keall, Lois Holloway
{"title":"I-III 期非小细胞肺癌患者常规临床实践中放疗方案的合规性。","authors":"Xiaoshui Huang,&nbsp;Matthew Field,&nbsp;Shalini Vinod,&nbsp;Helen Ball,&nbsp;Vikneswary Batumalai,&nbsp;Paul Keall,&nbsp;Lois Holloway","doi":"10.1111/1754-9485.13727","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Despite the availability of radiotherapy treatment protocols for lung cancer, considerable treatment variation occurs in clinical practice. This study assessed compliance with a radiotherapy protocol for the treatment of patients with stages I–III non-small-cell lung cancer (NSCLC) in routine clinical practice and to identify factors that were associated with compliance.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The Cancer Institute New South Wales eviQ treatment protocol for external beam radiotherapy of stages I–III NSCLC was taken as the reference to measure compliance. All inoperable patients with stages I–III NSCLC and documented ECOG performance status treated with radiotherapy between 2007 and 2019 at two radiotherapy facilities were available for analysis. Protocol compliance rates were calculated. Univariate and multivariate logistic regression models with 23 input factors were used to determine factors significantly associated with compliance. Survival analysis was conducted for both compliant and non-compliant treatments.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Overall, 656 patients met the inclusion criteria. Protocol compliance was 16%. Alternative dose/fractionation was responsible for 49% of non-compliant treatments with 30% receiving an alternative curative fractionation. Five of 23 factors (age at the start of radiotherapy, stage group, ECOG performance status, tumour location and alcoholism history) showed significant associations with protocol compliance on multivariate analysis. There was no significant difference in median survival between patients receiving protocol compliant treatment (15.1 months) and non-compliant treatment (15.6 months).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Adherence to the eviQ curative radiotherapy protocol for stages I–III NSCLC was low. Alternative dose/fractionation schemes were the main reason for non-compliance. Protocol compliance was not associated with outcome.</p>\n </section>\n </div>","PeriodicalId":16218,"journal":{"name":"Journal of Medical Imaging and Radiation Oncology","volume":"68 6","pages":"729-739"},"PeriodicalIF":2.2000,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1754-9485.13727","citationCount":"0","resultStr":"{\"title\":\"Radiotherapy protocol compliance in routine clinical practice for patients with stages I–III non-small-cell lung cancer\",\"authors\":\"Xiaoshui Huang,&nbsp;Matthew Field,&nbsp;Shalini Vinod,&nbsp;Helen Ball,&nbsp;Vikneswary Batumalai,&nbsp;Paul Keall,&nbsp;Lois Holloway\",\"doi\":\"10.1111/1754-9485.13727\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Despite the availability of radiotherapy treatment protocols for lung cancer, considerable treatment variation occurs in clinical practice. This study assessed compliance with a radiotherapy protocol for the treatment of patients with stages I–III non-small-cell lung cancer (NSCLC) in routine clinical practice and to identify factors that were associated with compliance.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The Cancer Institute New South Wales eviQ treatment protocol for external beam radiotherapy of stages I–III NSCLC was taken as the reference to measure compliance. All inoperable patients with stages I–III NSCLC and documented ECOG performance status treated with radiotherapy between 2007 and 2019 at two radiotherapy facilities were available for analysis. Protocol compliance rates were calculated. Univariate and multivariate logistic regression models with 23 input factors were used to determine factors significantly associated with compliance. Survival analysis was conducted for both compliant and non-compliant treatments.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Overall, 656 patients met the inclusion criteria. Protocol compliance was 16%. Alternative dose/fractionation was responsible for 49% of non-compliant treatments with 30% receiving an alternative curative fractionation. Five of 23 factors (age at the start of radiotherapy, stage group, ECOG performance status, tumour location and alcoholism history) showed significant associations with protocol compliance on multivariate analysis. There was no significant difference in median survival between patients receiving protocol compliant treatment (15.1 months) and non-compliant treatment (15.6 months).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Adherence to the eviQ curative radiotherapy protocol for stages I–III NSCLC was low. Alternative dose/fractionation schemes were the main reason for non-compliance. Protocol compliance was not associated with outcome.</p>\\n </section>\\n </div>\",\"PeriodicalId\":16218,\"journal\":{\"name\":\"Journal of Medical Imaging and Radiation Oncology\",\"volume\":\"68 6\",\"pages\":\"729-739\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-07-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1754-9485.13727\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Imaging and Radiation Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/1754-9485.13727\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Imaging and Radiation Oncology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1754-9485.13727","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

摘要

介绍:尽管目前已有肺癌放射治疗方案,但在临床实践中仍存在相当大的治疗差异。本研究评估了常规临床实践中I-III期非小细胞肺癌(NSCLC)患者对放射治疗方案的依从性,并找出与依从性相关的因素:方法:以新南威尔士癌症研究所制定的 I-III 期非小细胞肺癌体外射束放疗 eviQ 治疗方案为参照,衡量依从性。2007年至2019年期间,在两家放射治疗机构接受放射治疗的所有无法手术的I-III期NSCLC患者,以及记录在案的ECOG表现状态,均可用于分析。计算了协议符合率。使用包含 23 个输入因素的单变量和多变量逻辑回归模型来确定与依从性显著相关的因素。对依从和不依从治疗进行了生存分析:共有 656 名患者符合纳入标准。协议符合率为 16%。49%的不合规治疗患者接受了替代剂量/分次治疗,其中30%接受了替代治疗分次治疗。多变量分析显示,23个因素中有5个(开始放疗时的年龄、分期组别、ECOG表现状态、肿瘤位置和酗酒史)与方案依从性有显著关联。接受符合方案治疗(15.1个月)和不符合方案治疗(15.6个月)的患者的中位生存期没有明显差异:结论:I-III期NSCLC患者对eviQ根治性放疗方案的依从性较低。其他剂量/分次方案是不遵守方案的主要原因。方案依从性与疗效无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Radiotherapy protocol compliance in routine clinical practice for patients with stages I–III non-small-cell lung cancer

Radiotherapy protocol compliance in routine clinical practice for patients with stages I–III non-small-cell lung cancer

Introduction

Despite the availability of radiotherapy treatment protocols for lung cancer, considerable treatment variation occurs in clinical practice. This study assessed compliance with a radiotherapy protocol for the treatment of patients with stages I–III non-small-cell lung cancer (NSCLC) in routine clinical practice and to identify factors that were associated with compliance.

Methods

The Cancer Institute New South Wales eviQ treatment protocol for external beam radiotherapy of stages I–III NSCLC was taken as the reference to measure compliance. All inoperable patients with stages I–III NSCLC and documented ECOG performance status treated with radiotherapy between 2007 and 2019 at two radiotherapy facilities were available for analysis. Protocol compliance rates were calculated. Univariate and multivariate logistic regression models with 23 input factors were used to determine factors significantly associated with compliance. Survival analysis was conducted for both compliant and non-compliant treatments.

Results

Overall, 656 patients met the inclusion criteria. Protocol compliance was 16%. Alternative dose/fractionation was responsible for 49% of non-compliant treatments with 30% receiving an alternative curative fractionation. Five of 23 factors (age at the start of radiotherapy, stage group, ECOG performance status, tumour location and alcoholism history) showed significant associations with protocol compliance on multivariate analysis. There was no significant difference in median survival between patients receiving protocol compliant treatment (15.1 months) and non-compliant treatment (15.6 months).

Conclusion

Adherence to the eviQ curative radiotherapy protocol for stages I–III NSCLC was low. Alternative dose/fractionation schemes were the main reason for non-compliance. Protocol compliance was not associated with outcome.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.30
自引率
6.20%
发文量
133
审稿时长
6-12 weeks
期刊介绍: Journal of Medical Imaging and Radiation Oncology (formerly Australasian Radiology) is the official journal of The Royal Australian and New Zealand College of Radiologists, publishing articles of scientific excellence in radiology and radiation oncology. Manuscripts are judged on the basis of their contribution of original data and ideas or interpretation. All articles are peer reviewed.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信