ETV4/NSUN2轴调节有氧糖酵解和HSCC的恶性程度。

IF 3.1 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Human molecular genetics Pub Date : 2024-10-07 DOI:10.1093/hmg/ddae106

Xiaoxu Ding, Xueyan Zhang, Panxia Fang, Weiliang Bai

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引用次数: 0

摘要

这项研究深入探讨了下咽鳞状细胞癌（HSCC）的分子复杂性，特别关注了ETS易位变异体4（ETV4）在有氧糖酵解中发挥的关键作用。研究的目的是发现 HSCC 早期诊断和治疗的新靶点。我们严格研究了ETV4在HSCC组织中的表达，发现它与患者的存活率有关。通过全面的实验，我们证明了 ETV4 的激活会促进 HSCC 细胞的增殖和侵袭，同时抑制细胞凋亡。此外，体内实验也证实了 ETV4 激活的肿瘤促进效应。该研究阐明了ETV4与NSUN2启动子的结合及其对PKM2表达的影响，从而调控HSCC中的糖酵解和细胞功能。

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ETV4/NSUN2 Axis modulates aerobic glycolysis and malignancy in HSCC.

This study delves into the molecular intricacies of hypopharyngeal squamous cell carcinoma (HSCC), specifically focusing on the pivotal role played by ETS translocation variant 4 (ETV4) in aerobic glycolysis. The objective is to uncover new targets for early diagnosis and treatment of HSCC. ETV4 expression in HSCC tissues was rigorously examined, revealing its association with patient survival. Through comprehensive experimentation, we demonstrated that ETV4 activation promotes HSCC cell proliferation and invasion while inhibiting apoptosis. Furthermore, in vivo experiments confirmed the tumor-promoting effect of ETV4 activation. The study elucidated the binding of ETV4 to the NSUN2 promoter and its influence on PKM2 expression, thereby regulating glycolysis and cellular functions in HSCC.

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来源期刊

Human molecular genetics 生物-生化与分子生物学

CiteScore

6.90

自引率

2.90%

发文量

294

审稿时长

2-4 weeks

期刊介绍： Human Molecular Genetics concentrates on full-length research papers covering a wide range of topics in all aspects of human molecular genetics. These include: the molecular basis of human genetic disease developmental genetics cancer genetics neurogenetics chromosome and genome structure and function therapy of genetic disease stem cells in human genetic disease and therapy, including the application of iPS cells genome-wide association studies mouse and other models of human diseases functional genomics computational genomics In addition, the journal also publishes research on other model systems for the analysis of genes, especially when there is an obvious relevance to human genetics.