RILPL2是预测非小细胞肺癌T细胞浸润增强的潜在生物标记物。

IF 3.3 4区 医学 Q3 IMMUNOLOGY
Immunologic Research Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI:10.1007/s12026-024-09520-6
Dongfang Chen, Hongyan Zhang, Lifang Zhao, Xueqing Liu, Yueyan Lou, Peiling Wu, Shan Xue, Handong Jiang
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引用次数: 0

摘要

我们之前的生物信息学分析发现,Rab-interacting溶酶体蛋白样2(RILPL2)与非小细胞肺癌(NSCLC)的肿瘤免疫微环境相关。在我们的研究中,我们收集了140例原发性NSCLC患者,以验证RILPL2的表达及其预后价值、RILPL2表达与CD4+、CD8+T细胞浸润的关系。本研究共纳入了140例确诊为原发性NSCLC的患者(包括66例肺腺癌和74例肺鳞癌)。我们对这些患者进行了免疫组化(IHC)染色,以分析 RILPL2、CD4 和 CD8 的表达情况。与癌周组织相比,RILPL2在NSCLC组织中的表达明显降低(NSCLC中P + T细胞浸润(R = 0.294,NSCLC中P + T细胞浸润(R = 0.263,P = 0.002),LUAD亚组(R = 0.280,P = 0.023),LUSC亚组(R = 0.250,P = 0.031))。总之,RILPL2在NSCLC中表达下调;RILPL2低表达与较高分期和较差预后显著相关;RILPL2表达与CD4+、CD8+T细胞浸润显著正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

RILPL2 as a potential biomarker for predicting enhanced T cell infiltration in non-small cell lung cancer.

RILPL2 as a potential biomarker for predicting enhanced T cell infiltration in non-small cell lung cancer.

Our previous bioinformatics analysis has revealed that Rab-interacting lysosomal protein-like 2 (RILPL2) is associated with tumor immune microenvironment in non-small cell lung cancer (NSCLC). In our study, we collected 140 patients with primary NSCLC to verify the RILPL2 expression and its prognostic value, the relationship between RILPL2 expression and CD4+, CD8+T cell infiltration. A total of 140 patients who had been diagnosed with primary NSCLC (including 66 lung adenocarcinomas and 74 lung squamous cell carcinomas) were enrolled in our study. Immunohistochemical (IHC) staining was performed to analyze the expression of RILPL2, CD4, and CD8 in these patients. Compared with peri-cancer tissues, the RILPL2 expression in NSCLC tissues was significantly lower (P < 0.0001). RILPL2 expression was significantly related to clinical stage (P = 0.019), and low RILPL2 expression indicated higher stage. Low RILPL2 expression predicted worse overall survival (OS) in NSCLC patients (P = 0.017). Correlational analyses revealed that RILPL2 expression was significantly positively correlated with CD4+T cell infiltration in NSCLC (R = 0.294, P < 0.001), LUAD subgroup (R = 0.256, P = 0.038), and LUSC subgroup (R = 0.333, P = 0.004); RILPL2 expression was also significantly positively correlated with CD8+ T cell infiltration in NSCLC (R = 0.263, P = 0.002), LUAD subgroup (R = 0.280, P = 0.023), and LUSC subgroup (R = 0.250, P = 0.031). In conclusion, RILPL2 expression was downregulated in NSCLC; low RILPL2 expression was significantly related to higher stage and worse prognosis; RILPL2 expression was significantly positively correlated with CD4+, CD8+T cell infiltration.

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来源期刊
Immunologic Research
Immunologic Research 医学-免疫学
CiteScore
6.90
自引率
0.00%
发文量
83
审稿时长
6-12 weeks
期刊介绍: IMMUNOLOGIC RESEARCH represents a unique medium for the presentation, interpretation, and clarification of complex scientific data. Information is presented in the form of interpretive synthesis reviews, original research articles, symposia, editorials, and theoretical essays. The scope of coverage extends to cellular immunology, immunogenetics, molecular and structural immunology, immunoregulation and autoimmunity, immunopathology, tumor immunology, host defense and microbial immunity, including viral immunology, immunohematology, mucosal immunity, complement, transplantation immunology, clinical immunology, neuroimmunology, immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.
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