电纺纳米纤维:修复骨组织的构件。

IF 2.6 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Beilstein Journal of Nanotechnology Pub Date : 2024-07-25 eCollection Date: 2024-01-01 DOI:10.3762/bjnano.15.77
Tuğrul Mert Serim, Gülin Amasya, Tuğba Eren-Böncü, Ceyda Tuba Şengel-Türk, Ayşe Nurten Özdemir
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引用次数: 0

摘要

骨骼是人体最坚硬的结构之一,是骨骼系统的基本组成部分,它赋予人体形状,为肌肉和软组织提供机械支撑,并提供运动功能。即使没有损伤,骨重塑也是一个永久性的过程,以保持和更新骨组织的结构、生化和生物力学完整性。除了重塑,骨愈合也是一个非常复杂的过程,通过成骨细胞、骨细胞、破骨细胞和骨衬里细胞的和谐运作,修复骨组织的缺陷。各种材料既能触发骨愈合过程,又能为受损骨骼提供机械支撑。纳米纤维支架因其超大的表面积与体积比、小孔径和高孔隙率而在这类系统中处于领先地位。纳米纤维是众所周知的高功能系统,能够模拟天然骨基质的结构和功能,促进成骨细胞增殖和骨再生。电纺丝是一种简便快捷的方法,可生产由直径从微米到纳米的连续超细纤维组成的无纺结构。电纺丝技术简单、成本效益高,可使用多种合成、天然和混合聚合物,并能形成高多孔性的连续纤维,这些都是这种方法的显著特点。纳米纤维基支架在骨组织再生中的重要性与日俱增,因为它具有合适的孔径、高孔隙率、骨诱导、骨诱导骨生长、对目标区域的适应性、生物降解和适当的机械性能,这些都是聚合物骨移植物设计中重要的主要参数。本综述旨在阐明纳米纤维基支架在骨组织再生中越来越多的应用,并深入探讨骨再生、电纺纳米纤维的生产技术以及不同的配方参数,以实现不同的药物输送目标。本综述还对电纺纳米纤维进行了广泛的市场调研,并概述了该领域的科研和专利情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Electrospun nanofibers: building blocks for the repair of bone tissue.

Bone, one of the hardest structures of the body, is the basic constituent of the skeletal system, which gives the shape to the body, provides mechanical support for muscles and soft tissues, and provides movement. Even if there is no damage, bone remodeling is a permanent process to preserve and renew the structural, biochemical, and biomechanical integrity of bone tissue. Apart from the remodeling, bone healing is the highly complicated process of repairing deficiencies of bone tissue by the harmonious operation of osteoblasts, osteocytes, osteoclasts, and bone lining cells. Various materials can be used to both trigger the bone healing process and to provide mechanical support to damaged bone. Nanofiber scaffolds are at the forefront of these types of systems because of their extremely large surface area-to-volume ratio, small pore size, and high porosity. Nanofibers are known to be highly functional systems with the ability to mimic the structure and function of the natural bone matrix, facilitating osteogenesis for cell proliferation and bone regeneration. Electrospinning is an easy and fast method to produce non-woven structures consisting of continuous ultrafine fibers with diameters ranging from micrometers down to nanometers. The simplicity and cost-effectiveness of the electrospinning technique, its ability to use a wide variety of synthetic, natural, and mixed polymers, and the formation of highly porous and continuous fibers are the remarkable features of this method. The importance of nanofiber-based scaffolds in bone tissue regeneration is increasing because of suitable pore size, high porosity, osteoinduction, induction of bone growth with osteoconduction, adaptability to the target area, biodegradation, and appropriate mechanical properties, which are among the main parameters that are important in the design of polymeric bone grafts. The aim of this review is to cast light on the increasing use of nanofiber-based scaffolds in bone tissue regeneration and give an insight about bone regeneration, production techniques of the electrospun nanofibers, and varying formulation parameters in order to reach different drug delivery goals. This review also provides an extensive market research of electrospun nanofibers and an overview on scientific research and patents in the field.

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来源期刊
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
5.70
自引率
3.20%
发文量
109
审稿时长
2 months
期刊介绍: The Beilstein Journal of Nanotechnology is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in nanoscience and nanotechnology. The journal is published and completely funded by the Beilstein-Institut, a non-profit foundation located in Frankfurt am Main, Germany. The editor-in-chief is Professor Thomas Schimmel – Karlsruhe Institute of Technology. He is supported by more than 20 associate editors who are responsible for a particular subject area within the scope of the journal.
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