脂肪组织老化对心脏代谢的影响

IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Obesity Reviews Pub Date : 2024-07-30 DOI:10.1111/obr.13806
Bulbul Ahmed, Melissa G. Farb, Noyan Gokce
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引用次数: 0

摘要

脂肪组织是一个大型内分泌器官,具有多种生理功能。随着年龄的增长,脂肪组织会发生重塑和功能变化,从而改变其表型,可能导致代谢和心血管疾病。老化脂肪组织的特点是脂肪的区域性重新分布、衰老细胞的积累、纤维化和脂肪细胞分化能力的下降,这些都会影响脂肪组织的功能和全身健康。一个显著的变化是腹部内脏脂肪组织和内脏器官(如心脏、血管、肝脏和肾脏)周围的异位脂肪堆积增加,从而改变了它们的功能。与衰老相关的其他变化包括脂肪因子分泌的改变以及脂肪细胞大小和数量的变化。老化的脂肪细胞在慢性炎症、代谢功能障碍和胰岛素抵抗中起着介导作用。内脏脂肪组织的体积会随着衰老而增大,尤其与炎症、血管生成功能障碍和微血管异常有关,内脏脂肪释放的介质可能会对包括心血管系统在内的多个靶器官产生不利影响。了解脂肪组织老化的内在机制及其对心血管健康的影响,对于开发干预措施和治疗方法以促进健康老化和降低心血管代谢疾病风险非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiometabolic implications of adipose tissue aging

Adipose tissue is a large endocrine organ that serves numerous physiological functions. As we age, adipose tissue remodels and can develop functional changes that alters its phenotype, potentially contributing to metabolic and cardiovascular disorders. Aging adipose tissue is characterized by regional redistribution of fat, accumulation of senescent cells, fibrosis, and decline in adipocyte differentiation capacities, which collectively impact adipose tissue function and whole body health. A notable transformation involves increased accumulation of intra-abdominal visceral adipose tissue and ectopic fat around internal organs such as the heart, blood vessels, liver, and kidneys that alter their functions. Other changes associated with aging include alterations in adipokine secretion and changes in adipocyte size and numbers. Aging adipocytes play a role in mediating chronic inflammation, metabolic dysfunction, and insulin resistance. Visceral adipose tissue, which increases in volume with aging, is in particular associated with inflammation, angiogenic dysfunction, and microvascular abnormalities, and mediators released by visceral fat may have adverse consequences systemically in multiple target organs, including the cardiovascular system. Understanding mechanisms underlying adipose tissue aging and its impact on cardiovascular health are important for developing interventions and treatments to promote healthy aging and reduce cardiometabolic disease risk.

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来源期刊
Obesity Reviews
Obesity Reviews 医学-内分泌学与代谢
CiteScore
19.30
自引率
1.10%
发文量
130
审稿时长
1 months
期刊介绍: Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities. Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field. The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.
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