三级淋巴器官导致肾脏异体移植排斥反应

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY
Ellen F. Carney
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引用次数: 0

摘要

三级淋巴器官(TLO)是具有免疫调节作用的异位淋巴结构,在移植、癌症、自身免疫性疾病和感染等慢性炎症情况下出现。在次级淋巴组织正常的受者中,预先形成TLOs的F1-RIP-LTα肾脏的异体移植存活期明显短于移植时没有TLOs的肾脏,这表明TLOs加速了移植排斥反应。所有排斥的异体移植肾中都存在TLO。此外,在急性排斥反应模型中,供体小鼠LTβR的基因敲除可防止移植肾内TLO的形成,并延长异体移植肾的存活时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Tertiary lymphoid organs contribute to kidney allograft rejection

Tertiary lymphoid organs contribute to kidney allograft rejection
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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