在治疗癌前鳞状病变（光化性角化病）时采用两步光动力疗法减轻疼痛的临床试验。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2024-10-01 DOI:10.1016/j.pdpdt.2024.104294

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引用次数: 0

摘要

背景：氨基乙酰丙酸光动力疗法（ALA-PDT）治疗面部皮肤病时会产生疼痛，导致患者依从性低。两步光动力疗法（two-step PDT）可通过优化光幅和照射时间来提高舒适度：研究两步光动力疗法在减少面部皮肤疾病治疗过程中产生的疼痛方面的疗效：将 26 名 AK 患者随机分为两组，实验组采用两步光动力疗法，对照组采用常规光动力疗法。采用疼痛数字评分量表（NRS）评估患者在不同时间的疼痛强度：共有 26 名患者完成了三次 ALA-PDT 治疗，每组分别有 13 名和 13 名患者。实验组患者每次的平均 NRS 评分（3.28±1.41、3.33±1.43、3.42±1.78）均低于对照组（5.00±1.94、5.09±1.86、4.86±1.64）。实验组某些不良反应的发生率低于对照组。两组在临床疗效、复发率和患者满意度方面无差异：结论：两步光动力疗法可以减轻疼痛，降低某些不良反应的发生率，但不影响临床疗效、复发率和患者满意度。

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Clinical trial of two-step photodynamic therapy for reduced pain in the treatment of precancerous squamous lesions (Actinic keratoses)

Background

Pain associated with aminolevulinic acid photodynamic therapy (ALA-PDT) for the treatment of facial dermatoses results in low patient compliance. Two-step photodynamic therapy (two-step PDT) may improve comfort by optimizing light amplitude and exposure time.

Objective

To investigate the efficacy of two-step PDT in reducing the pain generated during the treatment of facial skin disorders.

Methods

Twenty-six patients with AK were randomly divided into two groups; the experimental group was treated with two-step photodynamic therapy and the control group was treated with conventional photodynamic therapy. The pain intensity of the patients at different times was assessed using the pain numerical rating scale (NRS).

Results

A total of 26 patients completed three ALA-PDT treatments, 13 and 13 patients in each group, respectively. The mean NRS scores of patients in the experimental group (3.28±1.41, 3.33±1.43, 3.42±1.78) were lower than those of the control group (5.00±1.94, 5.09±1.86, 4.86±1.64) on each occasion. The incidence of certain adverse reactions was lower in the experimental group than in the control group. There was no difference between the two groups in terms of clinical outcome, recurrence rate and patient satisfaction.

Conclusion

Two-step photodynamic therapy can reduce pain and the incidence of some adverse reactions, but does not affect clinical efficacy, recurrence rate and patient satisfaction.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.