{"title":"2021-2024 年中国西南地区帕金森病回顾性研究：基于年龄的方法。","authors":"Canrong Chen , Ding Zhang , Feiyu Chen , Donglin Wu , Wei Chen , Hongling Qin , Yueqiang Hu","doi":"10.1016/j.exger.2024.112532","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Globally, Parkinson's disease (PD) is one of the common neurodegenerative diseases in the elderly with increasing morbidity and disability, and its clinical pathogenesis is not clear.</p></div><div><h3>Objective</h3><p>To compare the differences in disease severity and blood biomarkers levels and their correlation between patients with early-onset Parkinson's disease (EOPD) and late-onset Parkinson's disease (LOPD).</p></div><div><h3>Methods</h3><p>A total of 342 patients diagnosed with PD were retrospectively collected. PD patients were categorized into EOPD (24 patients) and LOPD (318 patients) according to the age of onset of the disease. The Hoehn-Yahr (HY) staging was used to assess the severity of the disease in PD patients. Subjective rating scales such as the Mini-mental State Examination (MMSE) were used to assess the motor and non-motor functions of the patients. The differences of objective blood biomarkers such as triglyceride (TG) between the two groups were investigated. The correlation between them and PD was explored by logistic analysis.</p></div><div><h3>Results</h3><p>Percentage of EOPD group with HY staged as intermediate to late and Scales for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT), Movement Disorder Society-Unified Parkinson's disease Rating Scale-III (MDS-UPDRS-III), Montreal Cognitive Assessment (MoCA) score and TG, non-high-density lipoprotein-cholesterol (N-HDL-C), homocysteine (HCY), apolipoprotein B (Apo-B), free triiodothyronine (FT3), free thyroxine (FT4), high-sensitivity C-reactive protein (hs-CRP) levels were lower than those in the LOPD group (<em>P</em> < 0.05); and the proportion of HY staged as early stage, Hamilton Anxiety Scale (HAMA) and Fatigue severity scale (FSS) scores and the levels of vitamin B12 were higher than those in the LOPD group (<em>P</em> < 0.05). The results of Multifactorial Logistic regression analysis showed that N-HDL-C [OR = 1.409, 95 % CI (1.063, 1.868)], Apo-B [OR = 0.797, 95 % CI (0.638, 0.997)], Vitamin B12 [OR = 0.992, 95 % CI (0.987, 0.998)] and hs-CRP [OR = 1.124, 95 % CI (1.070, 1.182)] were independent factors affecting the severity of PD, with significant differences between groups (<em>P</em> < 0.05).</p></div><div><h3>Conclusion</h3><p>N-HDL-C, Apo-B, Vitamin B12, and hs-CRP levels play an important role in the progression of PD.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001748/pdfft?md5=0edcc672c5822b55cc78711bd1566bb6&pid=1-s2.0-S0531556524001748-main.pdf","citationCount":"0","resultStr":"{\"title\":\"A retrospective study of Parkinson's disease in Southwest China 2021–2024: An age-based approach\",\"authors\":\"Canrong Chen , Ding Zhang , Feiyu Chen , Donglin Wu , Wei Chen , Hongling Qin , Yueqiang Hu\",\"doi\":\"10.1016/j.exger.2024.112532\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Globally, Parkinson's disease (PD) is one of the common neurodegenerative diseases in the elderly with increasing morbidity and disability, and its clinical pathogenesis is not clear.</p></div><div><h3>Objective</h3><p>To compare the differences in disease severity and blood biomarkers levels and their correlation between patients with early-onset Parkinson's disease (EOPD) and late-onset Parkinson's disease (LOPD).</p></div><div><h3>Methods</h3><p>A total of 342 patients diagnosed with PD were retrospectively collected. PD patients were categorized into EOPD (24 patients) and LOPD (318 patients) according to the age of onset of the disease. The Hoehn-Yahr (HY) staging was used to assess the severity of the disease in PD patients. Subjective rating scales such as the Mini-mental State Examination (MMSE) were used to assess the motor and non-motor functions of the patients. The differences of objective blood biomarkers such as triglyceride (TG) between the two groups were investigated. The correlation between them and PD was explored by logistic analysis.</p></div><div><h3>Results</h3><p>Percentage of EOPD group with HY staged as intermediate to late and Scales for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT), Movement Disorder Society-Unified Parkinson's disease Rating Scale-III (MDS-UPDRS-III), Montreal Cognitive Assessment (MoCA) score and TG, non-high-density lipoprotein-cholesterol (N-HDL-C), homocysteine (HCY), apolipoprotein B (Apo-B), free triiodothyronine (FT3), free thyroxine (FT4), high-sensitivity C-reactive protein (hs-CRP) levels were lower than those in the LOPD group (<em>P</em> < 0.05); and the proportion of HY staged as early stage, Hamilton Anxiety Scale (HAMA) and Fatigue severity scale (FSS) scores and the levels of vitamin B12 were higher than those in the LOPD group (<em>P</em> < 0.05). 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引用次数: 0
摘要
背景：在全球范围内，帕金森病（Parkinson's disease，PD）是老年人常见的神经退行性疾病之一，发病率和致残率不断上升，其临床发病机制尚不清楚：比较早发型帕金森病（EOPD）和晚发型帕金森病（LOPD）患者在疾病严重程度和血液生物标志物水平上的差异及其相关性：方法：回顾性收集了342名被诊断为帕金森病的患者。根据发病年龄将帕金森病患者分为EOPD（24例）和LOPD（318例）。采用Hoehn-Yahr（HY）分期评估帕金森病患者的病情严重程度。主观评分量表（如迷你精神状态检查（MMSE））用于评估患者的运动和非运动功能。研究还调查了两组患者血液中甘油三酯（TG）等客观生物标志物的差异。结果发现，EOPD组患者中患有高血压的比例高于PD组：结果：EOPD 组中 HY 分期为中晚期的患者比例、帕金森病结果量表（SCOPA-AUT）、运动障碍协会-统一帕金森病评分量表-III（MDS-UPDRS-III）、蒙特利尔认知评估（MoCA）得分和甘油三酯（TG）、非高密度脂蛋白胆固醇 (N-HDL-C)、同型半胱氨酸 (HCY)、载脂蛋白 B (Apo-B)、游离三碘甲状腺原氨酸 (FT3)、游离甲状腺素 (FT4)、高敏 C 反应蛋白 (hs-CRP) 的水平均低于 LOPD 组（PN-HDL-C、载脂蛋白-B、维生素 B12 和 hs-CRP 水平在 PD 的进展过程中起着重要作用。
A retrospective study of Parkinson's disease in Southwest China 2021–2024: An age-based approach
Background
Globally, Parkinson's disease (PD) is one of the common neurodegenerative diseases in the elderly with increasing morbidity and disability, and its clinical pathogenesis is not clear.
Objective
To compare the differences in disease severity and blood biomarkers levels and their correlation between patients with early-onset Parkinson's disease (EOPD) and late-onset Parkinson's disease (LOPD).
Methods
A total of 342 patients diagnosed with PD were retrospectively collected. PD patients were categorized into EOPD (24 patients) and LOPD (318 patients) according to the age of onset of the disease. The Hoehn-Yahr (HY) staging was used to assess the severity of the disease in PD patients. Subjective rating scales such as the Mini-mental State Examination (MMSE) were used to assess the motor and non-motor functions of the patients. The differences of objective blood biomarkers such as triglyceride (TG) between the two groups were investigated. The correlation between them and PD was explored by logistic analysis.
Results
Percentage of EOPD group with HY staged as intermediate to late and Scales for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT), Movement Disorder Society-Unified Parkinson's disease Rating Scale-III (MDS-UPDRS-III), Montreal Cognitive Assessment (MoCA) score and TG, non-high-density lipoprotein-cholesterol (N-HDL-C), homocysteine (HCY), apolipoprotein B (Apo-B), free triiodothyronine (FT3), free thyroxine (FT4), high-sensitivity C-reactive protein (hs-CRP) levels were lower than those in the LOPD group (P < 0.05); and the proportion of HY staged as early stage, Hamilton Anxiety Scale (HAMA) and Fatigue severity scale (FSS) scores and the levels of vitamin B12 were higher than those in the LOPD group (P < 0.05). The results of Multifactorial Logistic regression analysis showed that N-HDL-C [OR = 1.409, 95 % CI (1.063, 1.868)], Apo-B [OR = 0.797, 95 % CI (0.638, 0.997)], Vitamin B12 [OR = 0.992, 95 % CI (0.987, 0.998)] and hs-CRP [OR = 1.124, 95 % CI (1.070, 1.182)] were independent factors affecting the severity of PD, with significant differences between groups (P < 0.05).
Conclusion
N-HDL-C, Apo-B, Vitamin B12, and hs-CRP levels play an important role in the progression of PD.
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