一种新的体外铀螯合试验，用于分析 3,4,3-LI(1,2-HOPO)在减少这种锕系元素对骨细胞的有害影响方面的有效性。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-07-25 DOI:10.1016/j.etap.2024.104518

Bastien Simoneau , Lucile Hurault , Georges F. Carle , Valérie Pierrefite-Carle , Sabine Santucci-Darmanin

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引用次数: 0

摘要

环境或职业暴露于天然铀会对健康产生不利影响，其化学毒性主要针对肾脏和骨骼。因此，人们开发了螯合剂来清除人体内的铀，其中包括配体 3,4,3-LI(1,2-HOPO)。我们开发了一种新的体外试验来评估 3,4,3-LI(1,2-HOPO)在减轻铀引起的骨细胞损伤方面的功效。这种方法使用的是破骨细胞，它们的形成和功能会因暴露于铀而发生改变。在评估新的铀装饰剂的有效性和安全性方面，该试验是一种有趣而有效的动物试验替代方法。

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A new in vitro uranium sequestration assay to analyze the effectiveness of 3,4,3-LI(1,2-HOPO) in reducing the harmful effects of this actinide on bone cells

Environmental or occupational exposure to natural uranium can have adverse health effects, with its chemical toxicity being mainly directed towards the kidneys and skeleton. This has led to the development of chelating agents to remove uranium from the human body, including the ligand 3,4,3-LI(1,2-HOPO). We have developed a new in vitro assay to assess the efficacy of 3,4,3-LI(1,2-HOPO) in attenuating uranium-induced bone cell damage. This approach uses osteoclasts whose formation and function are altered by exposure to uranium. This assay is an interesting and effective alternative to animal methods for assessing the efficacy and safety of new uranium decorporants.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.