血液中 AMPA 受体 GluA1 亚基自身抗体升高表明接触性运动运动员存在认知功能受损的风险,与脑震荡无关。

IF 1.8 Q3 CLINICAL NEUROLOGY
Neurotrauma reports Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI:10.1089/neur.2023.0132
Christopher Bailey, Daniel Soden, Joseph Maroon, Warren Selman, Christopher Tangen, John Gunstad, Susannah Briskin, Shana Miskovsky, Emiko Miller, Andrew A Pieper
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引用次数: 0

摘要

为了满足对运动员脑震荡客观测试的需求,我们在全国大学生体育协会的运动员中开展了一项前瞻性临床研究,探讨神经认知能力与血液中α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体肽的 GluA1 亚基水平以及 GluA1 自身抗体之间的关系。具体来说,我们对 44 名接触性运动运动员和 16 名非接触性运动运动员进行了比较,在赛季开始前和赛季结束时进行了脑震荡后即时评估和认知测试(ImPACT)以及血样采集。与赛季前的水平相比,接触性运动运动员在赛季结束时的血清 GluA1 自身抗体明显升高,无论他们是否受到脑震荡。非接触性运动运动员的血清 GluA1 自身抗体没有变化,两组运动员的 GluA1 肽也没有差异。在接触性运动运动员中,"高GluA1自身抗体组"(≥4纳克/毫升)显示出反应时间受损,而 "低GluA1自身抗体组"(≥4纳克/毫升)则显示出认知障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Elevated Autoantibodies to the GluA1 Subunit of the AMPA Receptor in Blood Indicate Risk of Cognitive Impairment in Contact Sports Athletes, Irrespective of Concussion.

To address the need for objective tests of concussion in athletes, we conducted a prospective clinical study in National Collegiate Athletic Association athletes of the relationship between neurocognitive performance and blood levels of the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor peptides and autoantibodies to GluA1. Specifically, we compared 44 contact sport athletes to 16 noncontact sport athletes, with Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT), as well as blood sample collection, before the start of the season and at the end of the season. Contact sport athletes exhibited significantly elevated serum GluA1 autoantibodies at the end of season, compared with preseason levels, irrespective of whether they sustained a concussion. Noncontact sport athletes showed no change in serum GluA1 autoantibodies, and neither group showed differences in GluA1 peptides. Amongst contact-sport athletes, the 'high GluA1 autoantibody group' (≥4 ng/mL) displayed impaired reaction time, a measure of cognitive impairment, while the 'low GluA1 autoantibody group' (<4 ng/mL) displayed normal reaction time. Our results reveal that contact sport athletes are at risk for developing cognitive impairment even without sustaining a diagnosed concussion and that serum GluA1 autoantibodies provide a blood-based biomarker of this risk. This could guide future studies on the differing susceptibility to cognitive impairment in contact sport athletes and facilitate efficient allocation of resources to contact sport athletes identified as having increased risk of developing cognitive impairment.

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CiteScore
2.40
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