小脑和镜像神经元系统:抑制问题?从神经生理学证据到神经调节影响。叙述性综述。

IF 7.5 1区 医学 Q1 BEHAVIORAL SCIENCES
Annibale Antonioni , Emanuela Maria Raho , Sofia Straudi , Enrico Granieri , Giacomo Koch , Luciano Fadiga
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引用次数: 0

摘要

镜像神经元在执行动作(AE)和观察动作(AO)时都有活动。镜像神经元系统(MNS)也可能参与运动想象(MI)。大量研究表明,小脑与镜像神经元系统相互关联,并可能在其活动中发挥关键作用。我们从理论和实验两方面收集了有关小脑在 MNS 功能中作用的证据。有证据表明,小脑在AO和MI过程中发挥着重要作用,小脑损伤会损害中枢神经系统功能,这可能是因为小脑通过调节大脑皮层具有镜像特性的抑制性中间神经元的活动,可能有助于视觉运动匹配,而视觉运动匹配是形成镜像特性的基础。事实上,小脑可能会加强感觉-运动模式,使预测结果与实际结果之间的差异最小化,无论是在AE还是在AO过程中都是如此。此外,通过与海马的连接,小脑可能参与了MI期间运动程序的内部模拟。最后,由于小脑神经调节可能会改善其对中枢神经系统活动的影响,我们探讨了其潜在的神经生理学和神经康复意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The cerebellum and the Mirror Neuron System: A matter of inhibition? From neurophysiological evidence to neuromodulatory implications. A narrative review

Mirror neurons show activity during both the execution (AE) and observation of actions (AO). The Mirror Neuron System (MNS) could be involved during motor imagery (MI) as well. Extensive research suggests that the cerebellum is interconnected with the MNS and may be critically involved in its activities. We gathered evidence on the cerebellum's role in MNS functions, both theoretically and experimentally. Evidence shows that the cerebellum plays a major role during AO and MI and that its lesions impair MNS functions likely because, by modulating the activity of cortical inhibitory interneurons with mirror properties, the cerebellum may contribute to visuomotor matching, which is fundamental for shaping mirror properties. Indeed, the cerebellum may strengthen sensory-motor patterns that minimise the discrepancy between predicted and actual outcome, both during AE and AO. Furthermore, through its connections with the hippocampus, the cerebellum might be involved in internal simulations of motor programs during MI. Finally, as cerebellar neuromodulation might improve its impact on MNS activity, we explored its potential neurophysiological and neurorehabilitation implications.

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来源期刊
CiteScore
14.20
自引率
3.70%
发文量
466
审稿时长
6 months
期刊介绍: The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.
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