用于预防耐多药细菌引起的呼吸机相关肺炎的低成本消毒浸渍气管造口管：体外和人体试验研究。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-26 DOI:10.1016/j.ram.2024.05.004

Juliano Gasparetto, Leandro Bressianini Jurkonis, Leticia Ramos Dantas, Paula Hansen Suss, Felipe Francisco Tuon

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引用次数: 0

摘要

呼吸机相关肺炎（VAP）是最常见的院内感染病因之一。本研究旨在评估用洗必泰和紫晶体浸渍的内部低成本气管造口管的抗菌和抗生物膜活性。浸渍过的气管造口管具有抗菌活性，包括对耐多药细菌的抗菌活性。对 14 名患者进行了评估。在通气过程中，涂层组有一名患者出现 VAP，对照组有三名患者出现 VAP（P=0.28）。观察到生物膜细胞有所减少。这项研究提供了初步证据，证明对气管造口管进行防腐浸渍具有显著的抗菌活性。

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Low-cost antiseptic-impregnated tracheostomy tube for the prevention of ventilator-associated pneumonia caused by multidrug-resistant bacteria: In vitro and pilot study in humans.

Ventilator-associated pneumonia (VAP) is one of the most common causes of nosocomial infections. The aim of this study was to evaluate the antimicrobial and anti-biofilm activity of an in-house low-cost tracheostomy tube impregnated with chlorhexidine and violet crystal. The impregnated tracheostomy tubes demonstrated antimicrobial activity, including for multidrug-resistant bacteria. Fourteen patients were evaluated. During ventilation, VAP occurred in one patient in the coated group and in three patients in the control group (p=0.28). A reduction of biofilm cells was observed. This study provides preliminary evidence to support that the antiseptic impregnation of a tracheostomy tube provides significant antimicrobial activity.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.