印度尼西亚高血压患者 ACE 插入/缺失基因多态性与卡托普利有效性的相关性。

IF 1.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI:10.1080/14622416.2024.2375190

Dewa A S Handani, Adam Hermawan, Zullies Ikawati

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引用次数: 0

摘要

背景：高血压是印尼普遍存在的健康问题，其中对 ACE 抑制剂治疗无效的患者比例很高。研究方法这项多中心病例对照研究调查了印尼高血压患者 ACE I/D 与卡托普利疗效之间的相关性。高血压患者被分为对照组（69 人）和病例组（73 人）。采用 PCR 和电泳技术鉴定 ACE I/D。结果显示基因型频率和等位基因分布无明显差异。三种基因型在降低血压方面的差异也缺乏统计学意义。结论：ACE I/D印尼高血压患者接受卡托普利治疗后，ACE I/D 与血压下降无明显关系。这些结果凸显了 ACE I/D 对使用卡托普利治疗高血压的预测作用有限。

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Correlation of ACE insertion/deletion gene polymorphism with captopril effectiveness in Indonesian hypertensive patients.

Background: Hypertension is a prevalent health concern in Indonesia, with a high percentage of patients unresponsive to ACE inhibitor treatment. Methods: This multicenter case-control study investigated the correlation between ACE I/D and captopril effectiveness in Indonesian hypertensive patients. Hypertensive patients were divided into control (n = 69) and case (n = 73) groups. ACE I/D was identified using PCR and electrophoresis.Results: No significant differences in genotype frequencies or allele distribution were observed. The difference of blood pressure reduction among the three genotypes also lacked statistical significance.Conclusion: ACE I/D is not significantly associated with blood pressure reduction following captopril therapy in Indonesian hypertensive patients. These results underscore the limited predictive utility of ACE I/D in managing hypertension with captopril.

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来源期刊

Pharmacogenomics 医学-药学

CiteScore

3.40

自引率

9.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.