根据基因组学诊断牙周病的前景与挑战。

IF 17.5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Periodontology 2000 Pub Date : 2024-06-01 Epub Date: 2024-07-28 DOI:10.1111/prd.12587
Luigi Nibali, Kimon Divaris, Emily Ming-Chieh Lu
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引用次数: 0

摘要

人类基因组学的最新进展和分子医学的出现,使我们描述人类健康和疾病特征的能力突飞猛进。科学家和医疗从业人员现在可以利用组织甚至单个细胞层面的遗传变异和基因表达信息,在完善诊断类别、评估未受影响个体的风险以及优化受影响个体的疾病管理方面潜力巨大。本综述探讨了分子医学和基因组学领域取得的进展,因为它们与牙周病学有关。综述总结了目前基因组学与牙周疾病相关的证据,包括目前的知识水平,即牙周炎人群中约三分之一的变异可能归因于基因变异,以及通过了解潜在的遗传原因可以加强对几种单基因疾病的管理。最后,本文结合目前在其他医学和医疗保健领域的应用,讨论了多基因风险评分和基因检测在目前和未来牙周炎诊断中的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The promise and challenges of genomics-informed periodontal disease diagnoses.

Recent advances in human genomics and the advent of molecular medicine have catapulted our ability to characterize human and health and disease. Scientists and healthcare practitioners can now leverage information on genetic variation and gene expression at the tissue or even individual cell level, and an enormous potential exists to refine diagnostic categories, assess risk in unaffected individuals, and optimize disease management among those affected. This review investigates the progress made in the domains of molecular medicine and genomics as they relate to periodontology. The review summarizes the current evidence of association between genomics and periodontal diseases, including the current state of knowledge that approximately a third of the population variance of periodontitis may be attributable to genetic variation and the management of several monogenic forms of the disease can be augmented by knowledge of the underlying genetic cause. Finally, the paper discusses the potential utility of polygenic risk scores and genetic testing for periodontitis diagnosis now and in the future, in light of applications that currently exist in other areas of medicine and healthcare.

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来源期刊
Periodontology 2000
Periodontology 2000 医学-牙科与口腔外科
CiteScore
34.10
自引率
2.20%
发文量
62
审稿时长
>12 weeks
期刊介绍: Periodontology 2000 is a series of monographs designed for periodontists and general practitioners interested in periodontics. The editorial board selects significant topics and distinguished scientists and clinicians for each monograph. Serving as a valuable supplement to existing periodontal journals, three monographs are published annually, contributing specialized insights to the field.
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