糖尿病伤口愈合中的免疫调节:巨噬细胞重编程与免疫治疗水凝胶的交集。

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING
Journal of Tissue Engineering Pub Date : 2024-07-27 eCollection Date: 2024-01-01 DOI:10.1177/20417314241265202
Dan Sun, Qiang Chang, Feng Lu
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引用次数: 0

摘要

由于全身代谢紊乱和局部炎症的相互作用阻碍了伤口愈合,糖尿病伤口愈合成为一项重大的临床挑战。巨噬细胞在伤口愈合过程中会发生从 M1 到 M2 的表型转变,这一转变对有效的组织修复至关重要。然而,在糖尿病伤口中,微环境会破坏这种表型极化,使炎症长期存在,阻碍伤口愈合。重新编程巨噬细胞以恢复其 M2 表型为调节伤口免疫微环境和促进愈合提供了一条潜在的途径。本综述阐明了糖尿病伤口中巨噬细胞向M2表型极化受损的机制,并讨论了促进巨噬细胞向M2转化的新策略,包括表观遗传和代谢干预。水凝胶具有水合三维交联结构,与生理细胞外基质非常相似,具有生物相容性、可调性和多功能性等优势。这些特性使得水凝胶有望成为开发免疫调节材料的候选材料,以解决糖尿病伤口问题。了解水凝胶在免疫疗法中的作用,尤其是在巨噬细胞重编程方面的作用,对于开发先进的伤口护理解决方案至关重要。本综述还重点介绍了免疫治疗水凝胶的最新进展,这是向精确有效地治疗糖尿病伤口迈出的一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunomodulation in diabetic wounds healing: The intersection of macrophage reprogramming and immunotherapeutic hydrogels.

Diabetic wound healing presents a significant clinical challenge due to the interplay of systemic metabolic disturbances and local inflammation, which hinder the healing process. Macrophages undergo a phenotypic shift from M1 to M2 during wound healing, a transition pivotal for effective tissue repair. However, in diabetic wounds, the microenvironment disrupts this phenotypic polarization, perpetuating inflammation, and impeding healing. Reprograming macrophages to restore their M2 phenotype offers a potential avenue for modulating the wound immune microenvironment and promoting healing. This review elucidates the mechanisms underlying impaired macrophage polarization toward the M2 phenotype in diabetic wounds and discusses novel strategies, including epigenetic and metabolic interventions, to promote macrophage conversion to M2. Hydrogels, with their hydrated 3D cross-linked structure, closely resemble the physiological extracellular matrix and offer advantageous properties such as biocompatibility, tunability, and versatility. These characteristics make hydrogels promising candidates for developing immunomodulatory materials aimed at addressing diabetic wounds. Understanding the role of hydrogels in immunotherapy, particularly in the context of macrophage reprograming, is essential for the development of advanced wound care solutions. This review also highlights recent advancements in immunotherapeutic hydrogels as a step toward precise and effective treatments for diabetic wounds.

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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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