{"title":"幽门螺旋杆菌阴性患者的胃内细菌感染和内窥镜检查结果。","authors":"Takashi Kawai, Yusuke Kawai, Yoshika Akimito, Mariko Hamada, Eri Iwata, Ryota Niikura, Naoyoshi Nagata, Kyosuke Yanagisawa, Masakatsu Fukuzawa, Takao Itoi, Mitsushige Sugimoto","doi":"10.3164/jcbn.24-56","DOIUrl":null,"url":null,"abstract":"<p><p>In the present study, the authors examined the association between gastric bacterial infection and gastric endoscopic findings in <i>Helicobacter pylori</i> (<i>H. pylori</i>)-negative patients. The subjects were 105 <i>H. pylori</i>-negative patients. The mean age was 72.8 ± 9.1 years. Endoscopy and gastric juice culture were performed. The presence or absence of endoscopic findings was checked according to the Kyoto classification of gastritis. Culture was positive in 69 patients (65.7%), with <i>Streptococcus</i> α-hemolytic being the most common (51 patients), followed by <i>Neisseria</i> sp. (43 patients). According to the univariate analysis, there was a significant difference between the results of culture and background factors in the use of gastric antisecretory drugs and between the results of culture and various endoscopic findings in atrophic gastritis, intestinal metaplasia, regular arrangement of collecting venule, mucosal swelling, sticky mucus, hyperplastic polyps, hematin, and gastric cobblestone-like lesions. Furthermore, multivariate analysis revealed significant differences in background factors such as the use of gastric antisecretory drugs and endoscopic findings only in patients with mucosal swelling. Endoscopic findings of non-<i>H. pylori</i> bacteria-positive gastritis differed from endoscopic findings of <i>H. pylori</i>-infected gastritis in several respects. In conclusion, our results suggest that non-<i>H. pylori</i> bacteria may infect the stomach and cause gastric inflammation, especially in patients who long term use gastric antisecretory drugs.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"75 1","pages":"65-70"},"PeriodicalIF":2.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273264/pdf/","citationCount":"0","resultStr":"{\"title\":\"Intragastric bacterial infection and endoscopic findings in <i>Helicobacter pylori</i>-negative patients.\",\"authors\":\"Takashi Kawai, Yusuke Kawai, Yoshika Akimito, Mariko Hamada, Eri Iwata, Ryota Niikura, Naoyoshi Nagata, Kyosuke Yanagisawa, Masakatsu Fukuzawa, Takao Itoi, Mitsushige Sugimoto\",\"doi\":\"10.3164/jcbn.24-56\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In the present study, the authors examined the association between gastric bacterial infection and gastric endoscopic findings in <i>Helicobacter pylori</i> (<i>H. pylori</i>)-negative patients. The subjects were 105 <i>H. pylori</i>-negative patients. The mean age was 72.8 ± 9.1 years. Endoscopy and gastric juice culture were performed. The presence or absence of endoscopic findings was checked according to the Kyoto classification of gastritis. Culture was positive in 69 patients (65.7%), with <i>Streptococcus</i> α-hemolytic being the most common (51 patients), followed by <i>Neisseria</i> sp. (43 patients). According to the univariate analysis, there was a significant difference between the results of culture and background factors in the use of gastric antisecretory drugs and between the results of culture and various endoscopic findings in atrophic gastritis, intestinal metaplasia, regular arrangement of collecting venule, mucosal swelling, sticky mucus, hyperplastic polyps, hematin, and gastric cobblestone-like lesions. Furthermore, multivariate analysis revealed significant differences in background factors such as the use of gastric antisecretory drugs and endoscopic findings only in patients with mucosal swelling. Endoscopic findings of non-<i>H. pylori</i> bacteria-positive gastritis differed from endoscopic findings of <i>H. pylori</i>-infected gastritis in several respects. In conclusion, our results suggest that non-<i>H. pylori</i> bacteria may infect the stomach and cause gastric inflammation, especially in patients who long term use gastric antisecretory drugs.</p>\",\"PeriodicalId\":15429,\"journal\":{\"name\":\"Journal of Clinical Biochemistry and Nutrition\",\"volume\":\"75 1\",\"pages\":\"65-70\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273264/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Biochemistry and Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3164/jcbn.24-56\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/4/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Biochemistry and Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3164/jcbn.24-56","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Intragastric bacterial infection and endoscopic findings in Helicobacter pylori-negative patients.
In the present study, the authors examined the association between gastric bacterial infection and gastric endoscopic findings in Helicobacter pylori (H. pylori)-negative patients. The subjects were 105 H. pylori-negative patients. The mean age was 72.8 ± 9.1 years. Endoscopy and gastric juice culture were performed. The presence or absence of endoscopic findings was checked according to the Kyoto classification of gastritis. Culture was positive in 69 patients (65.7%), with Streptococcus α-hemolytic being the most common (51 patients), followed by Neisseria sp. (43 patients). According to the univariate analysis, there was a significant difference between the results of culture and background factors in the use of gastric antisecretory drugs and between the results of culture and various endoscopic findings in atrophic gastritis, intestinal metaplasia, regular arrangement of collecting venule, mucosal swelling, sticky mucus, hyperplastic polyps, hematin, and gastric cobblestone-like lesions. Furthermore, multivariate analysis revealed significant differences in background factors such as the use of gastric antisecretory drugs and endoscopic findings only in patients with mucosal swelling. Endoscopic findings of non-H. pylori bacteria-positive gastritis differed from endoscopic findings of H. pylori-infected gastritis in several respects. In conclusion, our results suggest that non-H. pylori bacteria may infect the stomach and cause gastric inflammation, especially in patients who long term use gastric antisecretory drugs.
期刊介绍:
Journal of Clinical Biochemistry and Nutrition (JCBN) is
an international, interdisciplinary publication encompassing
chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The
Journal welcomes original contributions dealing with all
aspects of clinical biochemistry and clinical nutrition
including both in vitro and in vivo studies.