反驳啮齿动物增效剂消融模型在确定骨骼肌肥大的分子和细胞机制方面的实用性。

IF 5 2区生物学 Q2 CELL BIOLOGY

American journal of physiology. Cell physiology Pub Date : 2024-09-01 Epub Date: 2024-07-29 DOI:10.1152/ajpcell.00405.2024

Michael D Roberts, Troy A Hornberger, Stuart M Phillips

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引用次数: 0

摘要

在本期杂志中，Burke 等人讨论了啮齿类动物增效剂消融（SA）模型在研究骨骼肌肥大相关机制方面的实用性。在这篇特邀观点中，我们旨在通过讨论该模型的局限性以及具有优势和局限性的其他机械超负荷模型，对他们的原始观点进行补充。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The utility-and limitations-of the rodent synergist ablation model in examining mechanisms of skeletal muscle hypertrophy.

In this issue, Burke et al. discuss the utility of the rodent synergist ablation (SA) model for examining mechanisms associated with skeletal muscle hypertrophy. In this invited perspective, we aim to complement their original perspective by discussing limitations to the model along with alternative mechanical overload models that have strengths and limitations.

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来源期刊

American journal of physiology. Cell physiology 生物-生理学

CiteScore

9.10

自引率

1.80%

发文量

252

审稿时长

1 months

期刊介绍： The American Journal of Physiology-Cell Physiology is dedicated to innovative approaches to the study of cell and molecular physiology. Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly. Manuscripts dealing with the structure and function of cell membranes, contractile systems, cellular organelles, and membrane channels, transporters, and pumps are encouraged. Studies dealing with integrated regulation of cellular function, including mechanisms of signal transduction, development, gene expression, cell-to-cell interactions, and the cell physiology of pathophysiological states, are also eagerly sought. Interdisciplinary studies that apply the approaches of biochemistry, biophysics, molecular biology, morphology, and immunology to the determination of new principles in cell physiology are especially welcome.