Maurizio Bossola, Ilaria Mariani, Manuela Antocicco, Gilda Pepe, Enrico Di Stasio
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引用次数: 0
摘要
本系统综述和荟萃分析旨在比较碳酸氢盐血液透析和 HDF 对终末期肾病（ESRD）患者生活质量（QoL）、疲劳和康复时间的影响。于 2024 年 1 月在以下数据库中进行了搜索，并于 2024 年 3 月 3 日进行了更新：Ovid MEDLINE（1985 年至今）；Ovid EMBASE（1985 年至今）；Cochrane Library（Wiley）；PubMed（1985 年至今）。有 10 篇文章通过了全面的资格评估并被纳入调查。与 HD 相比，在线 HDF 的 SF-36 精神成分得分 (MCS) 的汇总 MD 为 0.98 (95% CI - 0.92, 2.87; P = 0.31)，身体成分得分 (PCS) 的汇总 MD 为 0.08 (95% CI - 1.32, 1.48; P = 0.91)。没有观察到明显的异质性（Chi2 = 4.85; I2 = 38%; P = 0.18 和 Chi2 = 3.85; I2 = 22%; P = 0.28）。通过肾脏疾病问卷或 KDQOL-SF 对 QoL 进行评估比较的研究表明，与 HD 相比，大多数研究中的 HDF 并未改善 QoL。在七项研究中，有五项研究表明，在改善疲劳方面，HDF并不比 HD 更有效。在本综述所包含的所有研究中，接受 HDF 和 HD 治疗的患者的恢复时间长度相似。在改善质量生活和疲劳以及缩短透析后恢复时间方面，HDF并不比 HD 更有效。
Effect of online hemodiafiltration on quality of life, fatigue and recovery time: a systematic review and meta-analysis
The present systematic review and meta-analysis aims to compare the effect of bicarbonate hemodialysis and HDF on quality of life (QoL), fatigue, and time to recovery in end-stage renal disease (ESRD) patients. Searches were run on January 2024 and updated on 3 March 2024 in the following databases: Ovid MEDLINE (1985 to present); Ovid EMBASE (1985 to present); Cochrane Library (Wiley); PubMed (1985 to present). Ten articles were fully assessed for eligibility and included in the investigation. Compared to HD, online HDF had a pooled MD of the mental component score (MCS) of the SF-36 of 0.98 (95% CI − 0.92, 2.87; P = 0.31). and of the physical component score (PCS) of 0.08 (95% CI − 1.32, 1.48; P = 0.91). No significant heterogeneity was observed (Chi2 = 4.85; I2 = 38%; P = 0.18 and Chi2 = 3.85; I2 = 22%; P = 0.28, respectively). Studies that compared the QoL assessed through the Kidney Disease Questionnaire or KDQOL-SF and show that HDF does not improve QoL when compared with HD, in most studies. In five out of seven studies, HDF was not significantly more effective than HD in improving fatigue. The length of the recovery time resulted in similar in patients receiving HDF and HD in all studies included in the present review. HDF is not more effective than HD in improving QoL and fatigue and in reducing the length of time of recovery after dialysis.
期刊介绍：
The aim of the Journal of Artificial Organs is to introduce to colleagues worldwide a broad spectrum of important new achievements in the field of artificial organs, ranging from fundamental research to clinical applications. The scope of the Journal of Artificial Organs encompasses but is not restricted to blood purification, cardiovascular intervention, biomaterials, and artificial metabolic organs. Additionally, the journal will cover technical and industrial innovations. Membership in the Japanese Society for Artificial Organs is not a prerequisite for submission.
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