{"title":"以热带碱基二icationic熔盐为活性催化剂，一步法合成吡啶并[2,3-d]嘧啶和 1,2,4-三唑并[4,3-a]嘧啶","authors":"Janan Metghalchi Langroudi, Masoumeh Mazloumi, Farhad Shirini, Hassan Tajik","doi":"10.1007/s40995-024-01685-x","DOIUrl":null,"url":null,"abstract":"<div><p>In this research, an environmentally friendly, effective method is documented for the synthesis of pyrido[2,3-<i>d</i>]pyrimidine and 1,2,4-triazolo[4,3-<i>a</i>]pyrimidine derivatives using an affordable and facile-prepared dicationic molten salt based on Tropine. The aforementioned pyrimidine derivatives have found remarkable pharmacological and therapeutic roles. under the influence of this catalyst formulated as [(Tropine)<sub>2</sub>C<sub>3</sub>H<sub>5</sub>OH].2Cl, the products are obtained during 50 to 120 and 15 to 70 min for both reactions respectively, along with high yields from 90 to 98% which was measured through chromatography method, under solvent-free conditions or in EtOH as a green solvent. Also, the catalyst can be easily recovered and reused at least for three times.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 5","pages":"1149 - 1159"},"PeriodicalIF":1.4000,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"One-Pot Synthesis of Pyrido[2,3-d]pyrimidines and 1,2,4-Triazolo[4,3−a]pyrimidines Using a Tropine-Based Dicationic Molten Salt as an Active Catalyst\",\"authors\":\"Janan Metghalchi Langroudi, Masoumeh Mazloumi, Farhad Shirini, Hassan Tajik\",\"doi\":\"10.1007/s40995-024-01685-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this research, an environmentally friendly, effective method is documented for the synthesis of pyrido[2,3-<i>d</i>]pyrimidine and 1,2,4-triazolo[4,3-<i>a</i>]pyrimidine derivatives using an affordable and facile-prepared dicationic molten salt based on Tropine. The aforementioned pyrimidine derivatives have found remarkable pharmacological and therapeutic roles. under the influence of this catalyst formulated as [(Tropine)<sub>2</sub>C<sub>3</sub>H<sub>5</sub>OH].2Cl, the products are obtained during 50 to 120 and 15 to 70 min for both reactions respectively, along with high yields from 90 to 98% which was measured through chromatography method, under solvent-free conditions or in EtOH as a green solvent. Also, the catalyst can be easily recovered and reused at least for three times.</p></div>\",\"PeriodicalId\":600,\"journal\":{\"name\":\"Iranian Journal of Science and Technology, Transactions A: Science\",\"volume\":\"48 5\",\"pages\":\"1149 - 1159\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Science and Technology, Transactions A: Science\",\"FirstCategoryId\":\"4\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40995-024-01685-x\",\"RegionNum\":4,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Science and Technology, Transactions A: Science","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1007/s40995-024-01685-x","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
One-Pot Synthesis of Pyrido[2,3-d]pyrimidines and 1,2,4-Triazolo[4,3−a]pyrimidines Using a Tropine-Based Dicationic Molten Salt as an Active Catalyst
In this research, an environmentally friendly, effective method is documented for the synthesis of pyrido[2,3-d]pyrimidine and 1,2,4-triazolo[4,3-a]pyrimidine derivatives using an affordable and facile-prepared dicationic molten salt based on Tropine. The aforementioned pyrimidine derivatives have found remarkable pharmacological and therapeutic roles. under the influence of this catalyst formulated as [(Tropine)2C3H5OH].2Cl, the products are obtained during 50 to 120 and 15 to 70 min for both reactions respectively, along with high yields from 90 to 98% which was measured through chromatography method, under solvent-free conditions or in EtOH as a green solvent. Also, the catalyst can be easily recovered and reused at least for three times.
期刊介绍：
The aim of this journal is to foster the growth of scientific research among Iranian scientists and to provide a medium which brings the fruits of their research to the attention of the world’s scientific community. The journal publishes original research findings – which may be theoretical, experimental or both - reviews, techniques, and comments spanning all subjects in the field of basic sciences, including Physics, Chemistry, Mathematics, Statistics, Biology and Earth Sciences
![One-Pot Synthesis of Pyrido[2,3-d]pyrimidines and 1,2,4-Triazolo[4,3−a]pyrimidines Using a Tropine-Based Dicationic Molten Salt as an Active Catalyst](https://img.booksci.cn/booksciimg/2024-7/2024072910270091151232.png)
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