黄酮类化合物与胃癌治疗：从信号通路到治疗意义

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL

Drug Design, Development and Therapy Pub Date : 2024-07-25 DOI:10.2147/dddt.s466470

Jiaying Cai, Xiyue Tan, Qichao Hu, Huafeng Pan, Maoyuan Zhao, Cui Guo, Jinhao Zeng, Xiao Ma, Yanling Zhao

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引用次数: 0

摘要

摘要：胃癌（GC）是一种常见的消化道肿瘤，具有高死亡率和高复发率的特点。目前的治疗方法往往存在局限性，这促使研究人员探索新型抗肿瘤物质并开发新药。黄酮类化合物是一种具有多种生物活性的天然化合物，在这方面正受到越来越多的关注。我们从 PubMed、Web of Science、SpringerLink 和其他数据库中检索了过去二十年的相关文献。以 "胃癌"、"胃癌"、"类黄酮"、"生物类黄酮"、"2-苯基-Chromene "为关键词进行检索，并对类黄酮治疗胃癌的机制进行了分析和总结。结果表明，黄酮类化合物的抗肿瘤机制包括抑制肿瘤生长、增殖、侵袭和转移，以及通过凋亡、自噬、铁凋亡和热凋亡等多种过程诱导细胞死亡。此外，将黄酮类化合物与其他化疗药物（如 5-FU 和铂化合物）结合使用有可能降低化疗耐药性。黄酮类化合物与其他天然产品联合使用时，还能增强生物活性。因此，本综述提出了将类黄酮开发为新型抗胃癌药物的创新观点。

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Flavonoids and Gastric Cancer Therapy: From Signaling Pathway to Therapeutic Significance

Abstract: Gastric cancer (GC) is a prevalent gastrointestinal tumor characterized by high mortality and recurrence rates. Current treatments often have limitations, prompting researchers to explore novel anti-tumor substances and develop new drugs. Flavonoids, natural compounds with diverse biological activities, are gaining increasing attention in this regard. We searched from PubMed, Web of Science, SpringerLink and other databases to find the relevant literature in the last two decades. Using “gastric cancer”, “stomach cancers”, “flavonoid”, “bioflavonoid”, “ 2-Phenyl-Chromene” as keywords, were searched, then analyzed and summarized the mechanism of flavonoids in the treatment of GC. It was revealed that the anti-tumor mechanism of flavonoids involves inhibiting tumor growth, proliferation, invasion, and metastasis, as well as inducing cell death through various processes such as apoptosis, autophagy, ferroptosis, and pyroptosis. Additionally, combining flavonoids with other chemotherapeutic agents like 5-FU and platinum compounds can potentially reduce chemoresistance. Flavonoids have also demonstrated enhanced biological activity when used in combination with other natural products. Consequently, this review proposes innovative perspectives for the development of flavonoids as new anti-GC agents.

Keywords: flavonoid, gastric cancer, apoptosis, angiogenesis

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.