Haifa A. Alqahtani, Dalal Mohamed Alshangiti, Nadiah Aldaleeli, Mohamed Madani, Samera Ali Al-Gahtany, Mohamed Mohamady Ghobashy
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Synergistic Gold Nanorod-based Chemo-Photothermal Therapy: A Promising Nanoparticle Approach for Refractory Multidrug-Resistant Cancer
Multidrug resistance (MDR) remains a formidable challenge in cancer treatment, necessitating innovative strategies to enhance therapeutic outcomes. This review explores the potential of a synergistic gold nanorod (GNR) therapy (SGNRT) utilizing GNRs as multifunctional platforms for co-delivering chemotherapy and thermal therapies. The rational design of SGNRT systems enables targeted payload delivery, circumvention of Adenosine triphosphate (ATP)-binding cassette drug efflux transporters, and hyperthermia-induced chemo sensitization. In vitro studies demonstrate the synergistic impact of SGNRT in overcoming MDR, emphasizing its potential for enhanced antitumor efficacy. However, further in vivo investigations are essential to assess the clinical viability of this nanoparticle (NP)-directed approach against advanced multidrug-resistant malignancies. The integration of SGNRT holds promise for advancing precision cancer therapies and addressing the intricate challenges of drug resistance in clinical settings.
ChemBioEng ReviewsBiochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
7.90
自引率
2.10%
发文量
45
期刊介绍：
Launched in 2014, ChemBioEng Reviews is aimed to become a top-ranking journal publishing review articles offering information on significant developments and provide fundamental knowledge of important topics in the fields of chemical engineering and biotechnology. The journal supports academics and researchers in need for concise, easy to access information on specific topics. The articles cover all fields of (bio-) chemical engineering and technology, e.g.,
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