K. A. Koshenskova, D. E. Baravikov, L. S. Razvorotneva, F. M. Dolgushin, O. B. Bekker, A. V. Khoroshilov, I. L. Eremenko, I. A. Lutsenko
{"title":"提高铜(ii)和锌(ii)配合物生物效率的方法:合成和结构方面、热特性和抗霉菌活性","authors":"K. A. Koshenskova, D. E. Baravikov, L. S. Razvorotneva, F. M. Dolgushin, O. B. Bekker, A. V. Khoroshilov, I. L. Eremenko, I. A. Lutsenko","doi":"10.1007/s11172-024-4299-2","DOIUrl":null,"url":null,"abstract":"<p>The reactions of copper(<span>ii</span>) and zinc(<span>ii</span>) acetates with anions of 5-phenylfuran-2-carboxylic acid (Hphfur) and 5-nitro-1,10-phenanthroline (nphen) or 2,2′-bipyridine (2,2′-bpy) in the MeOH/MeCN system afforded mononuclear complexes of the composition [Cu(phfur)<sub>2</sub>(nphen)H<sub>2</sub>O] (<b>1</b>) and [Zn(phfur)<sub>2</sub>(2,2′-bpy)]•H<sub>2</sub>O (<b>2</b>). The structures of these complexes were determined by X-ray diffraction analysis (XRD). According to the XRD data, the copper atom in molecular complex <b>1</b> is in a distorted square-pyramidal environment (<i>S</i><sub>Q</sub>(CuN<sub>2</sub>O<sub>3</sub>) = 0.68); the zinc atom in molecular complex <b>2</b>, in a distorted trigonal-bipyramidal environment (<i>S</i><sub>Q</sub>(ZnN<sub>2</sub>O<sub>3</sub>) = 3.87). The supramolecular level of <b>1</b> is mediated by intermolecular π–π interactions between the aromatic moieties of the ligands and represents a 3D supramolecular structure. in the structure of <b>2</b>, the water molecules of crystallization are involved in intermolecular hydrogen bonds, resulting in the formation of centrosymmetric hydrogen-bonded dimers. The supramolecular level of <b>2</b> is mediated by C—H⋯O and C—H⋯π interactions. According to the simultaneous thermal analysis, complexes <b>1</b> and <b>2</b> are characterized by different types of thermal destruction. Thus, the explosophoric groups in the ligands of compound <b>1</b> are responsible for an intense exothermic effect. The results of biological assays show a certain correlation between the type of the substituted moiety in the heterocycle and the activity against the non-pathogenic <i>Mycolicibacterium smegmatis</i> strain.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ways of enhancement of biological efficiency of copper(ii) and zinc(ii) complexes: synthetic and structural aspects, thermal properties, and antimycobacterial activity\",\"authors\":\"K. A. Koshenskova, D. E. Baravikov, L. S. Razvorotneva, F. M. Dolgushin, O. B. Bekker, A. V. Khoroshilov, I. L. Eremenko, I. A. Lutsenko\",\"doi\":\"10.1007/s11172-024-4299-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The reactions of copper(<span>ii</span>) and zinc(<span>ii</span>) acetates with anions of 5-phenylfuran-2-carboxylic acid (Hphfur) and 5-nitro-1,10-phenanthroline (nphen) or 2,2′-bipyridine (2,2′-bpy) in the MeOH/MeCN system afforded mononuclear complexes of the composition [Cu(phfur)<sub>2</sub>(nphen)H<sub>2</sub>O] (<b>1</b>) and [Zn(phfur)<sub>2</sub>(2,2′-bpy)]•H<sub>2</sub>O (<b>2</b>). The structures of these complexes were determined by X-ray diffraction analysis (XRD). According to the XRD data, the copper atom in molecular complex <b>1</b> is in a distorted square-pyramidal environment (<i>S</i><sub>Q</sub>(CuN<sub>2</sub>O<sub>3</sub>) = 0.68); the zinc atom in molecular complex <b>2</b>, in a distorted trigonal-bipyramidal environment (<i>S</i><sub>Q</sub>(ZnN<sub>2</sub>O<sub>3</sub>) = 3.87). The supramolecular level of <b>1</b> is mediated by intermolecular π–π interactions between the aromatic moieties of the ligands and represents a 3D supramolecular structure. in the structure of <b>2</b>, the water molecules of crystallization are involved in intermolecular hydrogen bonds, resulting in the formation of centrosymmetric hydrogen-bonded dimers. The supramolecular level of <b>2</b> is mediated by C—H⋯O and C—H⋯π interactions. According to the simultaneous thermal analysis, complexes <b>1</b> and <b>2</b> are characterized by different types of thermal destruction. Thus, the explosophoric groups in the ligands of compound <b>1</b> are responsible for an intense exothermic effect. The results of biological assays show a certain correlation between the type of the substituted moiety in the heterocycle and the activity against the non-pathogenic <i>Mycolicibacterium smegmatis</i> strain.</p>\",\"PeriodicalId\":756,\"journal\":{\"name\":\"Russian Chemical Bulletin\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Chemical Bulletin\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s11172-024-4299-2\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Bulletin","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s11172-024-4299-2","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Ways of enhancement of biological efficiency of copper(ii) and zinc(ii) complexes: synthetic and structural aspects, thermal properties, and antimycobacterial activity
The reactions of copper(ii) and zinc(ii) acetates with anions of 5-phenylfuran-2-carboxylic acid (Hphfur) and 5-nitro-1,10-phenanthroline (nphen) or 2,2′-bipyridine (2,2′-bpy) in the MeOH/MeCN system afforded mononuclear complexes of the composition [Cu(phfur)2(nphen)H2O] (1) and [Zn(phfur)2(2,2′-bpy)]•H2O (2). The structures of these complexes were determined by X-ray diffraction analysis (XRD). According to the XRD data, the copper atom in molecular complex 1 is in a distorted square-pyramidal environment (SQ(CuN2O3) = 0.68); the zinc atom in molecular complex 2, in a distorted trigonal-bipyramidal environment (SQ(ZnN2O3) = 3.87). The supramolecular level of 1 is mediated by intermolecular π–π interactions between the aromatic moieties of the ligands and represents a 3D supramolecular structure. in the structure of 2, the water molecules of crystallization are involved in intermolecular hydrogen bonds, resulting in the formation of centrosymmetric hydrogen-bonded dimers. The supramolecular level of 2 is mediated by C—H⋯O and C—H⋯π interactions. According to the simultaneous thermal analysis, complexes 1 and 2 are characterized by different types of thermal destruction. Thus, the explosophoric groups in the ligands of compound 1 are responsible for an intense exothermic effect. The results of biological assays show a certain correlation between the type of the substituted moiety in the heterocycle and the activity against the non-pathogenic Mycolicibacterium smegmatis strain.
期刊介绍:
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.