化学酶法全合成：实现化学和酶转化一体化的当前方法

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-07-23 DOI:10.3762/bjoc.20.151

Ryo Tanifuji, Hiroki Oguri

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引用次数: 0

摘要

摘要有关化学酶法合成方法的报道不断增加，这些方法将生物合成酶转化与化学转化结合在一起。本综述侧重于天然产物的全合成，并将酶促反应分为三类。概述了五种天然产物的全合成方法：子午烯醇、三萜醇、查尔科摩拉辛、泰内酯和沙夫霉素 A 以及它们的类似物，重点是将这些化学酶合成方法与相应的天然生物合成途径进行比较。Chem.2024, 20, 1693–1712. doi:10.3762/bjoc.20.151

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Chemo-enzymatic total synthesis: current approaches toward the integration of chemical and enzymatic transformations

Abstract

A steadily increasing number of reports have been published on chemo-enzymatic synthesis methods that integrate biosynthetic enzymatic transformations with chemical conversions. This review focuses on the total synthesis of natural products and classifies the enzymatic reactions into three categories. The total synthesis of five natural products: cotylenol, trichodimerol, chalcomoracin, tylactone, and saframycin A, as well as their analogs, is outlined with an emphasis on comparing these chemo-enzymatic syntheses with the corresponding natural biosynthetic pathways.

Beilstein J. Org. Chem. 2024, 20, 1693–1712. doi:10.3762/bjoc.20.151

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.