基于 WS2QDs 的高效非酶促荧光生物传感器用于监测水生介质中的氧氟沙星和环丙沙星

IF 3.5 Q2 CHEMISTRY, ANALYTICAL
Sunayana Bora and Chandan Upadhyay
{"title":"基于 WS2QDs 的高效非酶促荧光生物传感器用于监测水生介质中的氧氟沙星和环丙沙星","authors":"Sunayana Bora and Chandan Upadhyay","doi":"10.1039/D4SD00148F","DOIUrl":null,"url":null,"abstract":"<p >Quantum dot-based biosensors have gained prominence in recent times for the detection of biological and chemical hazards present in aquatic media which essentially contribute to the degradation of the environment and human health. Within this work, we demonstrate a WS<small><sub>2</sub></small> QD-induced turn-on fluorescent probe for specific monitoring of ofloxacin (OFL) and ciprofloxacin (CIP) residues in water. An efficient one-pot hydrothermal approach is applied for fluorescent water-soluble WS<small><sub>2</sub></small> QD preparation. The WS<small><sub>2</sub></small> QDs possess excellent photostability and monodispersity along with a superior shelf life. The WS<small><sub>2</sub></small> QDs interacting with FQns (OFL and CIP) showed a systematically enhanced fluorescence in varying FQn concentrations from 0 μM to 3 μM. Also, all the measurements showed excellent results for sensitivity along with superior specificity as well as anti-interference ability over other interfering substances like various metal ions and antibiotic derivatives. The proposed sensor allows the quantification of FQns in the range of 0–3 μM with the lowest detectable amount (LOD) of 0.08 μM and 0.06 μM and the minimal limit of quantification (LOQ) of 0.26 μM and 0.21 μM for both OFL and CIP, respectively, at natural pH. It achieved higher sensitivity than many established techniques and materials making up the gap of other existing systems in this range. We observed excellent results for the rapid <em>in situ</em> detection of FQns by implementing WS<small><sub>2</sub></small> QDs. The findings show potential for future use in real-time applications for FQns.</p>","PeriodicalId":74786,"journal":{"name":"Sensors & diagnostics","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/sd/d4sd00148f?page=search","citationCount":"0","resultStr":"{\"title\":\"Highly efficient WS2 QD-based non-enzymatic fluorescent biosensor for ofloxacin and ciprofloxacin monitoring in aquatic media†\",\"authors\":\"Sunayana Bora and Chandan Upadhyay\",\"doi\":\"10.1039/D4SD00148F\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Quantum dot-based biosensors have gained prominence in recent times for the detection of biological and chemical hazards present in aquatic media which essentially contribute to the degradation of the environment and human health. Within this work, we demonstrate a WS<small><sub>2</sub></small> QD-induced turn-on fluorescent probe for specific monitoring of ofloxacin (OFL) and ciprofloxacin (CIP) residues in water. An efficient one-pot hydrothermal approach is applied for fluorescent water-soluble WS<small><sub>2</sub></small> QD preparation. The WS<small><sub>2</sub></small> QDs possess excellent photostability and monodispersity along with a superior shelf life. The WS<small><sub>2</sub></small> QDs interacting with FQns (OFL and CIP) showed a systematically enhanced fluorescence in varying FQn concentrations from 0 μM to 3 μM. Also, all the measurements showed excellent results for sensitivity along with superior specificity as well as anti-interference ability over other interfering substances like various metal ions and antibiotic derivatives. The proposed sensor allows the quantification of FQns in the range of 0–3 μM with the lowest detectable amount (LOD) of 0.08 μM and 0.06 μM and the minimal limit of quantification (LOQ) of 0.26 μM and 0.21 μM for both OFL and CIP, respectively, at natural pH. It achieved higher sensitivity than many established techniques and materials making up the gap of other existing systems in this range. We observed excellent results for the rapid <em>in situ</em> detection of FQns by implementing WS<small><sub>2</sub></small> QDs. The findings show potential for future use in real-time applications for FQns.</p>\",\"PeriodicalId\":74786,\"journal\":{\"name\":\"Sensors & diagnostics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2024/sd/d4sd00148f?page=search\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sensors & diagnostics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2024/sd/d4sd00148f\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sensors & diagnostics","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/sd/d4sd00148f","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0

摘要

近来,基于量子点的生物传感器在检测水生介质中存在的生物和化学危害方面日益突出,这些危害从根本上导致了环境和人类健康的恶化。在这项工作中,我们展示了一种 WS2QDs 诱导的开启荧光探针,用于特异性监测水中的氧氟沙星(oflx)和环丙沙星(cprx)残留。该研究采用高效的一锅水热法制备了荧光水溶性 WS2QDs。WS2QDs 具有出色的光稳定性和单分散性,而且保存期极长。与 FQns(oflx 和 cprx)相互作用的 WS2QDs 在不同浓度(0μM 至 3μM)的 FQns 中显示出系统增强的荧光。此外,所有测量结果都显示出卓越的灵敏度、特异性和抗干扰能力,不受其他干扰物质(如各种金属离子和抗生素衍生物)的影响。在自然 pH 条件下,该传感器可对 0 μM-3 μM 范围内的 FQns 进行定量,最低检测量(LOD)分别为 0.12μM 和 2.02μM,最低定量限(LOQ)分别为 0.36μM 和 6.11μM。与许多已有的技术和材料相比,它实现了更高的灵敏度,弥补了其他现有系统在这一范围内的空白。通过使用 WS2QDs,我们观察到了快速原位检测 FQns 的出色结果。这些研究结果表明,它在未来的 FQns 实时应用中具有很大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Highly efficient WS2 QD-based non-enzymatic fluorescent biosensor for ofloxacin and ciprofloxacin monitoring in aquatic media†

Highly efficient WS2 QD-based non-enzymatic fluorescent biosensor for ofloxacin and ciprofloxacin monitoring in aquatic media†

Quantum dot-based biosensors have gained prominence in recent times for the detection of biological and chemical hazards present in aquatic media which essentially contribute to the degradation of the environment and human health. Within this work, we demonstrate a WS2 QD-induced turn-on fluorescent probe for specific monitoring of ofloxacin (OFL) and ciprofloxacin (CIP) residues in water. An efficient one-pot hydrothermal approach is applied for fluorescent water-soluble WS2 QD preparation. The WS2 QDs possess excellent photostability and monodispersity along with a superior shelf life. The WS2 QDs interacting with FQns (OFL and CIP) showed a systematically enhanced fluorescence in varying FQn concentrations from 0 μM to 3 μM. Also, all the measurements showed excellent results for sensitivity along with superior specificity as well as anti-interference ability over other interfering substances like various metal ions and antibiotic derivatives. The proposed sensor allows the quantification of FQns in the range of 0–3 μM with the lowest detectable amount (LOD) of 0.08 μM and 0.06 μM and the minimal limit of quantification (LOQ) of 0.26 μM and 0.21 μM for both OFL and CIP, respectively, at natural pH. It achieved higher sensitivity than many established techniques and materials making up the gap of other existing systems in this range. We observed excellent results for the rapid in situ detection of FQns by implementing WS2 QDs. The findings show potential for future use in real-time applications for FQns.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
2.30
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信