敲除 Stanniocalcin-1 可抑制口腔鳞状细胞癌细胞的生长和糖酵解过程

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-24 DOI:10.1515/biol-2022-0907

Chanyuan Wang, Jianpei Hu, Lijian Wang

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引用次数: 0

摘要

口腔鳞状细胞癌（OSCC）是头颈部鳞状细胞癌中最常见的恶性肿瘤。靶向治疗在口腔鳞状细胞癌的治疗中起着至关重要的作用。然而，更多新的靶点仍有待开发。斯坦尼钙素-1（STC-1）是一种糖蛋白激素，会影响癌症的进展。然而，STC-1在OSCC进展中的潜在作用仍有待探索。在此，我们旨在阐明STC-1在OSCC中的作用。我们发现，STC-1在OSCC组织中高表达，并与患者的不良预后相关。敲除 STC-1 能显著抑制 OSCC 细胞的生长，并通过减少葡萄糖消耗、ATP 生成和乳酸水平来抑制糖酵解。从机制上讲，STC-1消减抑制了PI3K/Akt通路，降低了PI3K和Akt的磷酸化水平。总之，STC-1消减可通过PI3K/Akt途径抑制OSCC细胞的生长和糖酵解，有望成为OSCC的治疗靶点。

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Knockdown of Stanniocalcin-1 inhibits growth and glycolysis in oral squamous cell carcinoma cells

Oral squamous cell carcinoma (OSCC) is the most common malignancy among head and neck squamous cell carcinomas. Targeted therapy plays a crucial role in the treatment of OSCC. However, new and more targets are still needed to develop. Stanniocalcin-1 (STC-1) is a glycoprotein hormone that affects the progression of cancers. However, the potential role of STC-1 in OSCC progression remains to be explored. Here, we aimed to elucidate the role of STC-1 in OSCC. We revealed that STC-1 was highly expressed in OSCC tissues and is correlated with poor patient prognosis. Knockdown of STC-1 significantly suppressed the growth of OSCC cells and restrained glycolysis by reducing glucose consumption, ATP production, and lactate levels. Mechanistically, STC-1 ablation inhibited the PI3K/Akt pathway, reducing the phosphorylation levels of PI3K and Akt. In conclusion, STC-1 depletion restrained OSCC cell growth and glycolysis via PI3K/Akt pathway and has the potential to serve as a therapeutic target for OSCC.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.