Trupti Kamani, Shobhit K. Patel, N. K. Anushkannan, Sana ben Khalifa, Saleh Chebaane, Taoufik Saidani
{"title":"利用细胞核和细胞质设计和开发用于早期检测宫颈癌的表面等离子体共振生物传感器","authors":"Trupti Kamani, Shobhit K. Patel, N. K. Anushkannan, Sana ben Khalifa, Saleh Chebaane, Taoufik Saidani","doi":"10.1007/s11468-024-02441-y","DOIUrl":null,"url":null,"abstract":"<p>Cervical cancer is a significant risk to women’s lives, and early detection is crucial to secure patient quality of life. Currently, doctors’ diagnosis relies on their subjective assessments, as there is no standardized measuring method. The problem can be solved with the optical biosensor as it provides precise and quick consequences in the determination of cancerous cells. This manuscript presents a novel double c-shaped copper-based refractivity biosensor (DCSCRIB) for the recognition of cervical nucleus as well as cervical cytoplasm cells. The double c-shaped copper-based resonator provides high spatial resolution, upper sensitivity, and upper-quality factor making them for novel choice to detect the nucleus and cytoplasm of cervical cancer. The upper sensitivity (<i>S</i>) has been spotted at 1600 nm/RIU for the cervical nucleus with the upper-quality factor (QF) being 1618.37 for the cervical cytoplasm. The upper rate of the figure of merit (FOM) is 1107.18, the detection area (DR) rate is 1925.17, the signal noise ratio (SNR) rate is 33.2155, and the sensor resolution (SR) rate is 0.93 which has been spotted of cervical cytoplasm. The upper detection limit of 0.0004 has been achieved for the natural cytoplasm. This propounded sensor can highly intellect the cervical cancer biomarkers.</p>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design and Development of Surface Plasmon Resonance Biosensor for Early Detection of Cervical Cancer Utilizing Nucleus and Cytoplasm\",\"authors\":\"Trupti Kamani, Shobhit K. Patel, N. K. Anushkannan, Sana ben Khalifa, Saleh Chebaane, Taoufik Saidani\",\"doi\":\"10.1007/s11468-024-02441-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Cervical cancer is a significant risk to women’s lives, and early detection is crucial to secure patient quality of life. Currently, doctors’ diagnosis relies on their subjective assessments, as there is no standardized measuring method. The problem can be solved with the optical biosensor as it provides precise and quick consequences in the determination of cancerous cells. This manuscript presents a novel double c-shaped copper-based refractivity biosensor (DCSCRIB) for the recognition of cervical nucleus as well as cervical cytoplasm cells. The double c-shaped copper-based resonator provides high spatial resolution, upper sensitivity, and upper-quality factor making them for novel choice to detect the nucleus and cytoplasm of cervical cancer. The upper sensitivity (<i>S</i>) has been spotted at 1600 nm/RIU for the cervical nucleus with the upper-quality factor (QF) being 1618.37 for the cervical cytoplasm. The upper rate of the figure of merit (FOM) is 1107.18, the detection area (DR) rate is 1925.17, the signal noise ratio (SNR) rate is 33.2155, and the sensor resolution (SR) rate is 0.93 which has been spotted of cervical cytoplasm. The upper detection limit of 0.0004 has been achieved for the natural cytoplasm. This propounded sensor can highly intellect the cervical cancer biomarkers.</p>\",\"PeriodicalId\":736,\"journal\":{\"name\":\"Plasmonics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-07-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasmonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1007/s11468-024-02441-y\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasmonics","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1007/s11468-024-02441-y","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Design and Development of Surface Plasmon Resonance Biosensor for Early Detection of Cervical Cancer Utilizing Nucleus and Cytoplasm
Cervical cancer is a significant risk to women’s lives, and early detection is crucial to secure patient quality of life. Currently, doctors’ diagnosis relies on their subjective assessments, as there is no standardized measuring method. The problem can be solved with the optical biosensor as it provides precise and quick consequences in the determination of cancerous cells. This manuscript presents a novel double c-shaped copper-based refractivity biosensor (DCSCRIB) for the recognition of cervical nucleus as well as cervical cytoplasm cells. The double c-shaped copper-based resonator provides high spatial resolution, upper sensitivity, and upper-quality factor making them for novel choice to detect the nucleus and cytoplasm of cervical cancer. The upper sensitivity (S) has been spotted at 1600 nm/RIU for the cervical nucleus with the upper-quality factor (QF) being 1618.37 for the cervical cytoplasm. The upper rate of the figure of merit (FOM) is 1107.18, the detection area (DR) rate is 1925.17, the signal noise ratio (SNR) rate is 33.2155, and the sensor resolution (SR) rate is 0.93 which has been spotted of cervical cytoplasm. The upper detection limit of 0.0004 has been achieved for the natural cytoplasm. This propounded sensor can highly intellect the cervical cancer biomarkers.
期刊介绍：
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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