防止晶体凝聚：机理、因素和添加剂的影响

IF 2.4 4区材料科学 Q2 CRYSTALLOGRAPHY

Crystals Pub Date : 2024-07-24 DOI:10.3390/cryst14080676

Huixiang Zhang, Shichao Du, Yan Wang, Fumin Xue

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引用次数: 0

摘要

结晶团聚是大多数化学品和药品的常见现象。结块的形成通常会降低产品的纯度，并产生广泛的粒度分布。本综述侧重于防止溶液结晶、晶体储存和药物制备过程中的结块现象。本文分析了这些阶段的结块机理，并总结了操作参数的影响。此外，还阐述了与结晶环境有关的有效控制手段，包括溶剂、超声波和添加剂。其中特别关注了添加剂在防止悬浮液和干燥粉末聚集方面的影响。除了用于溶液结晶的添加剂外，还讨论了抗结块剂、纳米悬浮剂的稳定剂和固体分散剂辅料的作用。添加剂的类型和特性（如亲水性、疏水性、离子强度、粘度、立体阻碍效应以及添加剂与晶体之间的分子间相互作用）会在很大程度上影响团聚程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prevention of Crystal Agglomeration: Mechanisms, Factors, and Impact of Additives

Crystal agglomeration is a common phenomenon for most chemicals and pharmaceuticals. The formation of agglomerates usually lowers product purity and generates a broad particle size distribution. This review focuses on preventing agglomeration in solution crystallization, the storage of crystals, and pharmaceutical preparation processes. The agglomeration mechanisms in these stages are analyzed and the effects of operating parameters are summarized. Furthermore, effective control means related to the crystallization environment are elaborated, including solvents, ultrasound, and additives. Special attention is paid to the influence of additives in preventing the aggregation of both suspensions and dried powders. Besides additives used in solution crystallization, the roles of anti-caking agents, stabilizers of nanosuspensions, and excipients of solid dispersions are also discussed. The additive type and properties like hydrophilicity, hydrophobicity, ionic strength, viscosity, the steric hindrance effect, and intermolecular interactions between additives and crystals can greatly affect the degree of agglomeration.

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来源期刊

Crystals CRYSTALLOGRAPHYMATERIALS SCIENCE, MULTIDIS-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

4.20

自引率

11.10%

发文量

1527

审稿时长

16.12 days

期刊介绍： Crystals (ISSN 2073-4352) is an open access journal that covers all aspects of crystalline material research. Crystals can act as a reference, and as a publication resource, to the community. It publishes reviews, regular research articles, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Full experimental details must be provided to enable the results to be reproduced. Crystals provides a forum for the advancement of our understanding of the nucleation, growth, processing, and characterization of crystalline materials. Their mechanical, chemical, electronic, magnetic, and optical properties, and their diverse applications, are all considered to be of importance.