Kota Kubo, Aya Hirata, Aya Kadota, Akiko Harada, Yasuyuki Nakamura, Takehito Hayakawa, Naoyuki Takashima, Akira Fujiyoshi, Yukiko Okami, Yoshikuni Kita, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, for the NIPPON DATA90 Research Group
{"title":"基于日本 25 年随访期间全国生命统计的心力衰竭和冠状动脉疾病死亡率风险因素 - NIPPON DATA90 - NIPPON DATA91","authors":"Kota Kubo, Aya Hirata, Aya Kadota, Akiko Harada, Yasuyuki Nakamura, Takehito Hayakawa, Naoyuki Takashima, Akira Fujiyoshi, Yukiko Okami, Yoshikuni Kita, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, for the NIPPON DATA90 Research Group","doi":"10.1253/circj.cj-23-0847","DOIUrl":null,"url":null,"abstract":"</p><p><b><i>Background:</i></b> Prevention of heart failure (HF) is a public health issue. Using the National Vital Statistics, we explored risk factors for HF and coronary artery disease (CAD) mortality.</p><p><b><i>Methods and Results:</i></b> Altogether, 7,556 Japanese individuals aged ≥30 years in 1990 were followed over 25 years; of these, 139 and 154 died from HF and CAD, respectively. In multivariable Cox proportional hazard analysis, common risk factors for CAD and HF mortality were hypertension (hazard ratio [HR] 1.48 [95% confidence interval {CI} 1.00–2.20] and 2.31 [95% CI 1.48–3.61], respectively), diabetes (HR 2.52 [95% CI 1.63–3.90] and 2.07 [95% CI 1.23–3.50], respectively), and current smoking (HR 2.05 [95% CI 1.27–3.31) and 1.86 [95% CI 1.10–3.15], respectively). Specific risk factors for CAD were male sex, chronic kidney disease, history of cardiovascular disease, and both abnormal T and Q waves, with HRs (95% CIs) of 1.75 (1.05–2.92), 1.78 (1.19–2.66), 2.50 (1.62–3.88), and 11.4 (3.64–36.0), respectively. Specific factors for HF were current drinking (HR 0.43; 95% CI 0.24–0.78) and non-high-density lipoprotein cholesterol (non-HDL-C; HR 0.81; 95% CI 0.67–0.98). There was an inverse association between non-HDL-C and HF in those aged ≥65 years (HR 0.71; 95% CI 0.56–0.90), but not in those aged <65 years.</p><p><b><i>Conclusions:</i></b> We identified common risk factors for HF and CAD deaths; a history of cardiovascular disease was a specific risk for CAD.</p>\n<p></p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Risk Factors for Heart Failure and Coronary Artery Disease Mortality Based on the National Vital Statistics During a 25-Year Follow-up in Japan ― NIPPON DATA90 ―\",\"authors\":\"Kota Kubo, Aya Hirata, Aya Kadota, Akiko Harada, Yasuyuki Nakamura, Takehito Hayakawa, Naoyuki Takashima, Akira Fujiyoshi, Yukiko Okami, Yoshikuni Kita, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, for the NIPPON DATA90 Research Group\",\"doi\":\"10.1253/circj.cj-23-0847\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"</p><p><b><i>Background:</i></b> Prevention of heart failure (HF) is a public health issue. Using the National Vital Statistics, we explored risk factors for HF and coronary artery disease (CAD) mortality.</p><p><b><i>Methods and Results:</i></b> Altogether, 7,556 Japanese individuals aged ≥30 years in 1990 were followed over 25 years; of these, 139 and 154 died from HF and CAD, respectively. In multivariable Cox proportional hazard analysis, common risk factors for CAD and HF mortality were hypertension (hazard ratio [HR] 1.48 [95% confidence interval {CI} 1.00–2.20] and 2.31 [95% CI 1.48–3.61], respectively), diabetes (HR 2.52 [95% CI 1.63–3.90] and 2.07 [95% CI 1.23–3.50], respectively), and current smoking (HR 2.05 [95% CI 1.27–3.31) and 1.86 [95% CI 1.10–3.15], respectively). Specific risk factors for CAD were male sex, chronic kidney disease, history of cardiovascular disease, and both abnormal T and Q waves, with HRs (95% CIs) of 1.75 (1.05–2.92), 1.78 (1.19–2.66), 2.50 (1.62–3.88), and 11.4 (3.64–36.0), respectively. Specific factors for HF were current drinking (HR 0.43; 95% CI 0.24–0.78) and non-high-density lipoprotein cholesterol (non-HDL-C; HR 0.81; 95% CI 0.67–0.98). There was an inverse association between non-HDL-C and HF in those aged ≥65 years (HR 0.71; 95% CI 0.56–0.90), but not in those aged <65 years.</p><p><b><i>Conclusions:</i></b> We identified common risk factors for HF and CAD deaths; a history of cardiovascular disease was a specific risk for CAD.</p>\\n<p></p>\",\"PeriodicalId\":50691,\"journal\":{\"name\":\"Circulation Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-07-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Circulation Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1253/circj.cj-23-0847\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Circulation Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1253/circj.cj-23-0847","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
背景:预防心力衰竭(HF)是一个公共卫生问题。我们利用全国人口动态统计资料,探讨了高血压和冠状动脉疾病(CAD)死亡率的风险因素:我们对 1990 年年龄≥30 岁的 7,556 名日本人进行了长达 25 年的跟踪调查,其中分别有 139 人和 154 人死于高血压和冠心病。在多变量考克斯比例危险分析中,导致 CAD 和 HF 死亡的常见危险因素是高血压(危险比 [HR] 分别为 1.48 [95% 置信区间 {CI} 1.00-2.20] 和 2.31 [95% CI 1.48-3.61])、糖尿病(HR 分别为 2.52 [95% CI 1.63-3.90] 和 2.07 [95% CI 1.23-3.50])以及目前吸烟(HR 分别为 2.05 [95% CI 1.27-3.31] 和 1.86 [95% CI 1.10-3.15])。男性、慢性肾病、心血管疾病史、T 波和 Q 波异常是导致 CAD 的特定风险因素,其 HR 值(95% CI)分别为 1.75(1.05-2.92)、1.78(1.19-2.66)、2.50(1.62-3.88)和 11.4(3.64-36.0)。导致心房颤动的特定因素是目前饮酒(HR 0.43;95% CI 0.24-0.78)和非高密度脂蛋白胆固醇(non-HDL-C;HR 0.81;95% CI 0.67-0.98)。在年龄≥65岁的人群中,非高密度脂蛋白胆固醇与心房颤动呈反向关系(HR 0.71;95% CI 0.56-0.90),但在年龄<65岁的人群中则没有这种关系:我们发现了导致高血压和冠心病死亡的共同风险因素;心血管疾病史是导致冠心病死亡的特定风险因素。
Risk Factors for Heart Failure and Coronary Artery Disease Mortality Based on the National Vital Statistics During a 25-Year Follow-up in Japan ― NIPPON DATA90 ―
Background: Prevention of heart failure (HF) is a public health issue. Using the National Vital Statistics, we explored risk factors for HF and coronary artery disease (CAD) mortality.
Methods and Results: Altogether, 7,556 Japanese individuals aged ≥30 years in 1990 were followed over 25 years; of these, 139 and 154 died from HF and CAD, respectively. In multivariable Cox proportional hazard analysis, common risk factors for CAD and HF mortality were hypertension (hazard ratio [HR] 1.48 [95% confidence interval {CI} 1.00–2.20] and 2.31 [95% CI 1.48–3.61], respectively), diabetes (HR 2.52 [95% CI 1.63–3.90] and 2.07 [95% CI 1.23–3.50], respectively), and current smoking (HR 2.05 [95% CI 1.27–3.31) and 1.86 [95% CI 1.10–3.15], respectively). Specific risk factors for CAD were male sex, chronic kidney disease, history of cardiovascular disease, and both abnormal T and Q waves, with HRs (95% CIs) of 1.75 (1.05–2.92), 1.78 (1.19–2.66), 2.50 (1.62–3.88), and 11.4 (3.64–36.0), respectively. Specific factors for HF were current drinking (HR 0.43; 95% CI 0.24–0.78) and non-high-density lipoprotein cholesterol (non-HDL-C; HR 0.81; 95% CI 0.67–0.98). There was an inverse association between non-HDL-C and HF in those aged ≥65 years (HR 0.71; 95% CI 0.56–0.90), but not in those aged <65 years.
Conclusions: We identified common risk factors for HF and CAD deaths; a history of cardiovascular disease was a specific risk for CAD.
期刊介绍:
Circulation publishes original research manuscripts, review articles, and other content related to cardiovascular health and disease, including observational studies, clinical trials, epidemiology, health services and outcomes studies, and advances in basic and translational research.