吡喃酮衍生物在抑制藤壶沉降和生物膜形成方面的结构-功能活性

IF 2.6 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Mo Aqib Raza Khan, Bo-Wei Wang, Hsiu-Chin Lin, Yu-Liang Yang, Chih-Chuang Liaw
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引用次数: 0

摘要

天然存在的 6-戊基-2H-吡喃-2-酮及其合成类似物能极大地抑制两栖类水蚤(Amphibalanus amphitrite cyprids)的沉降以及海洋细菌的生长和生物膜的形成。为了优化吡喃酮衍生物的防污活性,本研究通过改变吡喃酮两侧取代的苄基、环戊烷和卤化物等官能团,设计了吡喃酮类似物。随后,评估了合成的吡喃酮衍生物对五种海洋生物成膜细菌(香港鲎杆菌、同种葡萄球菌、无患子葡萄球菌、天使光杆菌和马克洛德单胞菌)以及两栖类藤壶胞体的防污效果。与 6-戊基-2H-吡喃-2-酮相比,取代非极性部分(如 C-5 上的脂肪族、环戊基或苯基分子或 C-3 上的呋喃分子)不仅能提高抗菌活性和抑制生物膜的形成,还能抑制藤壶囊虫的沉降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Structure-Functional Activity of Pyrone Derivatives for Inhibition of Barnacle Settlement and Biofilm Formation

Structure-Functional Activity of Pyrone Derivatives for Inhibition of Barnacle Settlement and Biofilm Formation

Structure-Functional Activity of Pyrone Derivatives for Inhibition of Barnacle Settlement and Biofilm Formation

Naturally occurring 6-pentyl-2H-pyran-2-one and its synthetic analogues greatly inhibit the settlement of Amphibalanus amphitrite cyprids and the growth and biofilm formation of marine bacteria. To optimize the antifouling activities of pyrone derivatives, this study designed pyrone analogues by modifying functional groups, such as the benzyl group, cyclopentane, and halides, substituted on both sides of a pyrone. The antifouling effects of the synthesized pyrone derivatives were subsequently evaluated against five marine biofilm–forming bacteria, Loktanella hongkongensis, Staphylococcus cohnii, S. saprophyticus, Photobacterium angustum, and Alteromonas macleodii, along with barnacle cyprids of Amphibalanus amphitrite. Substituting nonpolar parts—such as the aliphatic, cyclopentyl, or phenyl moieties on C-5 or the furan moieties on C-3—not only increased antibacterial activity and inhibited biofilm formation but also inhibited barnacle cyprid settlement when compared to 6-pentyl-2H-pyran-2-one.

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来源期刊
Marine Biotechnology
Marine Biotechnology 工程技术-海洋与淡水生物学
CiteScore
4.80
自引率
3.30%
发文量
95
审稿时长
2 months
期刊介绍: Marine Biotechnology welcomes high-quality research papers presenting novel data on the biotechnology of aquatic organisms. The journal publishes high quality papers in the areas of molecular biology, genomics, proteomics, cell biology, and biochemistry, and particularly encourages submissions of papers related to genome biology such as linkage mapping, large-scale gene discoveries, QTL analysis, physical mapping, and comparative and functional genome analysis. Papers on technological development and marine natural products should demonstrate innovation and novel applications.
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