Nienke H van Teijlingen, Marleen Y van Smoorenburg, Ramin Sarrami-Forooshani, Esther M Zijlstra-Willems, John L van Hamme, Hanneke Borgdorff, Janneke H H M van de Wijgert, Elisabeth van Leeuwen, Joris A M van der Post, Karin Strijbis, Carla M S Ribeiro, Teunis B H Geijtenbeek
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引用次数: 0
摘要
阴道微生物群失调对人类免疫缺陷病毒 1 型（HIV-1）的性传播构成严重威胁。在阴道菌群失调期间，普雷沃特氏菌大量存在，并与 HIV-1 易感性增强有关；然而，其潜在机制仍不清楚。在此，我们研究了阴道细菌对阴道 CD4+ T 细胞的 HIV-1 易感性的直接影响。值得注意的是，预先暴露于Prevotella timonensis会增强阴道T细胞对HIV-1的摄取，导致病毒融合增加和病毒生成增强。而预先暴露于抗逆转录病毒抑制剂则会消除P timonensis增强感染的作用。我们的研究表明，阴道微生物群直接影响粘膜 CD4+ T 细胞的易感性，这强调了阴道菌群失调诊断和治疗的重要性。
Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells.
Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis-enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4+ T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment.
期刊介绍：
Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.
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