多微生物感染研究的过去、现在和未来:建模、窃听、地球化和其他故事。

Advances in microbial physiology Pub Date : 2024-01-01 Epub Date: 2024-05-22 DOI:10.1016/bs.ampbs.2024.04.002
Éva Bernadett Bényei, Rahan Rudland Nazeer, Isabel Askenasy, Leonardo Mancini, Pok-Man Ho, Gordon A C Sivarajan, Jemima E V Swain, Martin Welch
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引用次数: 0

摘要

在过去的两个世纪中,微生物学作为一门学科取得了巨大进步。这些进步很大程度上是通过在定义明确的实验室培养基(即所谓的 "轴向生长")中研究单个微生物物种的生长和生理学而取得的。然而,在现实世界中,微生物很少生活在如此 "与世隔绝 "的环境中(借用福斯特的话说),它们往往与大量的共栖生物共享生态位。由此产生的物种之间(甚至王国之间)的相互作用,无论是在理论层面还是在实验层面,人们都知之甚少。在本综述中,我们将评估多微生物感染的重要性,并说明实验牵引的改进如何促进我们对多微生物感染的了解。我们将特别关注那些能让我们捕捉到多微生物感染情景的关键特征的发展,尤其是那些与人体气道(包括健康气道和患病气道)相关的多微生物感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The past, present and future of polymicrobial infection research: Modelling, eavesdropping, terraforming and other stories.

Over the last two centuries, great advances have been made in microbiology as a discipline. Much of this progress has come about as a consequence of studying the growth and physiology of individual microbial species in well-defined laboratory media; so-called "axenic growth". However, in the real world, microbes rarely live in such "splendid isolation" (to paraphrase Foster) and more often-than-not, share the niche with a plethora of co-habitants. The resulting interactions between species (and even between kingdoms) are only very poorly understood, both on a theoretical and experimental level. Nevertheless, the last few years have seen significant progress, and in this review, we assess the importance of polymicrobial infections, and show how improved experimental traction is advancing our understanding of these. A particular focus is on developments that are allowing us to capture the key features of polymicrobial infection scenarios, especially as those associated with the human airways (both healthy and diseased).

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