颅内动脉瘤的动物模型:历史、进展和未来展望。

IF 3.8 2区 医学 Q1 CLINICAL NEUROLOGY
Hiroki Uchikawa, Redi Rahmani
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引用次数: 0

摘要

颅内动脉瘤(IA)是一种具有潜在破坏性后果的疾病,尤其是当动脉瘤破裂导致蛛网膜下腔出血时。虽然存在一些候选药物,但目前还没有确定的药物可以预防动脉瘤的生长和破裂。开发预防性治疗方法是一个关键的研究领域,而使用动物的临床前模型则起着举足轻重的作用。这些模型采用不同的物种和诱导方法,各具特色,可根据研究的具体目标加以利用。我们总结了动物模型在内脏瘤研究中的重要作用,尤其侧重于大鼠、小鼠和大型动物。我们总结了动物模型在动脉瘤研究中的重要作用,尤其关注大鼠和小鼠以及大型动物。我们讨论了每种模型的优缺点,深入探讨了它们的独特性以及对我们了解动脉瘤的贡献。对这些模型的深入了解对于推进IA的预防性治疗研究至关重要。通过利用每种模型的独特优势并承认其局限性,研究人员可以开展更有效、更有针对性的研究。这反过来又能加快新型治疗策略的开发,使我们更接近建立有效的IA预防性治疗方法的目标。本综述旨在全面介绍IA研究中动物模型的现状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Animal Models of Intracranial Aneurysms: History, Advances, and Future Perspectives.

Animal Models of Intracranial Aneurysms: History, Advances, and Future Perspectives.

Intracranial aneurysms (IA) are a disease process with potentially devastating outcomes, particularly when rupture occurs leading to subarachnoid hemorrhage. While some candidates exist, there is currently no established pharmacological prevention of growth and rupture. The development of prophylactic treatments is a critical area of research, and preclinical models using animals play a pivotal role. These models, which utilize various species and induction methods, each possess unique characteristics that can be leveraged depending on the specific aim of the study. A comprehensive understanding of these models, including their historical development, is crucial for appreciating the advantages and limitations of aneurysm research in animal models.We summarize the significant roles of animal models in IA research, with a particular focus on rats, mice, and large animals. We discuss the pros and cons of each model, providing insights into their unique characteristics and contributions to our understanding of IA. These models have been instrumental in elucidating the pathophysiology of IA and in the development of potential therapeutic strategies.A deep understanding of these models is essential for advancing research on preventive treatments for IA. By leveraging the unique strengths of each model and acknowledging their limitations, researchers can conduct more effective and targeted studies. This, in turn, can accelerate the development of novel therapeutic strategies, bringing us closer to the goal of establishing an effective prophylactic treatment for IA. This review aims to provide a comprehensive view of the current state of animal models in IA research.

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来源期刊
Translational Stroke Research
Translational Stroke Research CLINICAL NEUROLOGY-NEUROSCIENCES
CiteScore
13.80
自引率
4.30%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Translational Stroke Research covers basic, translational, and clinical studies. The Journal emphasizes novel approaches to help both to understand clinical phenomenon through basic science tools, and to translate basic science discoveries into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma. Translational Stroke Research focuses on translational research and is relevant to both basic scientists and physicians, including but not restricted to neuroscientists, vascular biologists, neurologists, neuroimagers, and neurosurgeons.
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