饮食限制下癌症能量代谢的最新进展:小型综述。

IF 2.8 4区 医学 Q2 ONCOLOGY
Liuxin Yang, Yudian Shao, Tingting Gao, Ousman Bajinka, Xingxing Yuan
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引用次数: 0

摘要

操纵癌细胞的能量或食物来源已引起肿瘤学研究的极大关注。对免疫系统进行代谢重编程可以加深对癌细胞机制的了解,从而阻碍其发展。一种更有针对性的方法是通过饮食限制(CR)来限制癌细胞,使癌细胞无法获得肿瘤微环境中的首选能量来源,从而提高免疫细胞的功效。虽然有大量的 CR 策略可用于阻碍癌症进展,但目前还没有全面的综述来描述针对癌细胞不同代谢途径的特定饮食限制。这篇微型综述介绍了作为抗癌剂的氨基酸,并讨论了饮食干预在癌症预防和治疗中的作用。它强调了生酮饮食作为癌症治疗方法的潜力,阐明了其在肿瘤进展中的独特作用机制。此外,还讨论了植物性膳食作为抗癌剂的潜力、多酚和维生素在抗癌治疗中的作用,以及 CR 作为抗肿瘤进展的一些前瞻性干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Current advances in cancer energy metabolism under dietary restriction: a mini review.

Current advances in cancer energy metabolism under dietary restriction: a mini review.

The manipulation of the energy or source of food for cancer cells has attracted significant attention in oncology research. Metabolic reprogramming of the immune system allows for a deeper understanding of cancer cell mechanisms, thereby impeding their progression. A more targeted approach is the restriction of cancer cells through dietary restriction (CR), which deprives cancer cells of the preferred energy sources within the tumor microenvironment, thereby enhancing immune cell efficacy. Although there is a plethora of CR strategies that can be employed to impede cancer progression, there is currently no comprehensive review that delineates the specific dietary restrictions that target the diverse metabolic pathways of cancer cells. This mini-review introduces amino acids as anti-cancer agents and discusses the role of dietary interventions in cancer prevention and treatment. It highlights the potential of a ketogenic diet as a therapeutic approach for cancer, elucidating its distinct mechanisms of action in tumor progression. Additionally, the potential of plant-based diets as anti-cancer agents and the role of polyphenols and vitamins in anti-cancer therapy were also discussed, along with some prospective interventions for CR as anti-tumor progression.

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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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