利用干细胞治疗口腔干燥症:系统综述。

IF 1.9 3区 医学 Q2 OTORHINOLARYNGOLOGY
Ioanna Aritzi, Iordanis Konstantinidis, Artemis Kyriakidou, Konstantinos Garefis, Giorgos Sideris, Alexander Delides
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引用次数: 0

摘要

简介口腔干燥症的性质复杂,因此无法确定治愈方法。最近,研究转向干细胞移植用于腺体重建。本研究旨在对现有研究进行最新综述,强调所遇到的挑战和研究途径,从而提高干细胞移植的治疗应用潜力:本研究根据PRISMA指南,使用以下数据库进行系统综述:PubMed(PMC)、PMC Europe、Scopus、Medline、Research Gate、Elsevier。主要问题是干细胞疗法是否有助于治疗口腔干燥症:226篇出版物中有19篇符合本综述的标准,包括 "体内"、"体外 "研究和临床试验。所有19项研究都详细描述了干细胞来源和移植方法,并记录了基于分析和统计方法确认的结果。数据显示,不同来源的干细胞发挥了重要作用,其中骨髓或脂肪组织来源的多能胚泡是最常用的。小鼠的人体移植也已被接受,并逆转了唾液腺功能减退症。尤其是对接受过放射治疗(IR)或表现出类似斯约格伦综合症(SS)症状的模型,其效果更为显著。这表明,无论疾病的原因是什么,只要采用适当的治疗和富集技术,干细胞移植似乎都是有效的。腺体和干细胞的提取物和联合培养似乎也能改善腺体功能:结论:尽管干细胞的使用还处于初始阶段,但它似乎是一种很有前景的疗法,无论口腔干燥症的原因是什么,它都能缓解口腔干燥症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The use of stem cells in treating xerostomia: a systematic review.

The use of stem cells in treating xerostomia: a systematic review.

Introduction: The complex nature of xerostomia prevents the establishment of a definite cure. Recently, research has pivoted towards stem cell transplantation for glandular reconstruction. The aim of this study is to provide an updated review of the existing research, to highlight the encountered challenges and research pathways, potentially enhancing the therapeutic applications of stem cell transplantation.

Methods: This is a systematic review according to PRISMA guidelines, using the following databases: PubMed (PMC), PMC Europe, Scopus, Medline, Research Gate, Elsevier. The main question was whether stem cell therapies can contribute to the treatment of xerostomia.

Results: 19 of 226 publications met the criteria for this review, including 'in vivo', 'in vitro' studies and clinical trials. All 19 studies described thoroughly the stem cell source and the transplantation method, and documented results based on analytical and statistical methods of confirmation. Data show that the various sources of stem cells play a significant role, with bone marrow or adipose tissue-derived pluripotent blasts being the most utilized. Human transplants in mice have also been accepted and reversed hyposalivation. The effects have been beneficial especially in models undergone radiotherapy (IR) or exhibit Sjogren Syndrome-like symptoms (SS), suggesting that with appropriate treatment and enrichment techniques, stem cell transplantation seems effective regardless of the cause of the disorder. Extracts and co-cultures of gland and stem cells also seem to improve gland function.

Conclusion: Although in its initial stages, the use of stem cells seems to be a promising therapy to alleviate xerostomia regardless of its cause.

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来源期刊
CiteScore
5.30
自引率
7.70%
发文量
537
审稿时长
2-4 weeks
期刊介绍: Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.
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