先锋转录因子的阴与阳：抑制与激活的双重作用

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

BioEssays Pub Date : 2024-07-26 DOI:10.1002/bies.202400138

Takeshi Katsuda, Jonathan H. Sussman, Kenneth S. Zaret, Ben Z. Stanger

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引用次数: 0

摘要

先锋转录因子能够靶向沉默染色质中的核糖体 DNA，因此在发育和细胞重编程过程中诱导细胞命运决定方面发挥着至关重要的作用。除了在染色质开放以激活基因表达程序方面的公认作用外，最近的研究还表明，先驱因子还具有互补功能，即能够通过靶向染色质抑制来沉默起始细胞特性。鉴于最近关于先驱因子抑制功能方面的发现，我们将讨论先驱因子在细胞命运控制中抑制替代系程序的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The yin and yang of pioneer transcription factors: Dual roles in repression and activation

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The yin and yang of pioneer transcription factors: Dual roles in repression and activation

Pioneer transcription factors, by virtue of their ability to target nucleosomal DNA in silent chromatin, play crucial roles in eliciting cell fate decisions during development and cellular reprogramming. In addition to their well-established role in chromatin opening to activate gene expression programs, recent studies have demonstrated that pioneer factors have the complementary function of being able to silence the starting cell identity through targeted chromatin repression. Given recent discoveries regarding the repressive aspect of pioneer function, we discuss the basis by which pioneer factors can suppress alternative lineage programs in the context of cell fate control.

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来源期刊

BioEssays 生物-生化与分子生物学

CiteScore

7.30

自引率

2.50%

发文量

167

审稿时长

4-8 weeks

期刊介绍： molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.