{"title":"根据治疗前的111In-索马他汀受体闪烁扫描预测177Lu-DOTATATE治疗后第二天的1厘米剂量当量率。","authors":"Go Takai, Kohei Hanaoka, Keiji Nagano, Tsutomu Okada, Maya Honda, Izumi Komoto","doi":"10.1007/s12149-024-01962-0","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>When patients administered <sup>177</sup>Lu-DOTATATE are released or discharged from rooms where radiopharmaceuticals are used, the time required for release or discharge varies across patients. This study investigated whether the amount of radioactivity accumulated on <sup>111</sup>In-somatostatine receptor scintigraphy (<sup>111</sup>In-SRS) performed prior to treatment can predict the 1 cm dose-equivalent rate at a distance of 1 m from the patient on the day after <sup>177</sup>Lu-DOTATATE administration.</p><h3>Methods</h3><p>Whole-body planar <sup>111</sup>In-SRS images were acquired for 21 patients. Pixel values within whole-body and abdominal (35 × 25 cm) regions of interest (ROIs) were converted to radioactivity dose (MBq). The 1 cm dose-equivalent rate (µSv/h) at a distance of 1 m from the patient 18.3 ± 0.5 h after administration of <sup>177</sup>Lu-DOTATATE was measured using an ionization survey meter.</p><h3>Results</h3><p>The following relationships were observed between the radioactivity on <sup>111</sup>In-SRS and the 1 cm dose-equivalent rate on the day after administration of <sup>177</sup>Lu-DOTATATE: whole-body ROI: <i>y</i> = 0.16<i>x</i> + 5.01 (<i>r</i> = 0.56, <i>p</i> = 0.009), abdominal ROI: <i>y</i> = 0.27<i>x</i> + 5.13 (<i>r</i> = 0.63, <i>p</i> = 0.002). The regression equations indicate that patients cannot be released or discharged from the radiopharmaceutical room the day after <sup>177</sup>Lu-DOTATATE administration if the whole-body and abdominal ROI doses are greater than 81 and 48 MBq, respectively, on <sup>111</sup>In-SRS.</p><h3>Conclusions</h3><p>The amount of radioactivity accumulated on <sup>111</sup>In-SRS may be a predictor of release criteria for patients receiving <sup>177</sup>Lu-DOTATATE.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prediction of 1 cm dose-equivalent rate on the day after administration of 177Lu-DOTATATE from 111In-somatostatine receptor scintigraphy prior to treatment\",\"authors\":\"Go Takai, Kohei Hanaoka, Keiji Nagano, Tsutomu Okada, Maya Honda, Izumi Komoto\",\"doi\":\"10.1007/s12149-024-01962-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>When patients administered <sup>177</sup>Lu-DOTATATE are released or discharged from rooms where radiopharmaceuticals are used, the time required for release or discharge varies across patients. This study investigated whether the amount of radioactivity accumulated on <sup>111</sup>In-somatostatine receptor scintigraphy (<sup>111</sup>In-SRS) performed prior to treatment can predict the 1 cm dose-equivalent rate at a distance of 1 m from the patient on the day after <sup>177</sup>Lu-DOTATATE administration.</p><h3>Methods</h3><p>Whole-body planar <sup>111</sup>In-SRS images were acquired for 21 patients. Pixel values within whole-body and abdominal (35 × 25 cm) regions of interest (ROIs) were converted to radioactivity dose (MBq). The 1 cm dose-equivalent rate (µSv/h) at a distance of 1 m from the patient 18.3 ± 0.5 h after administration of <sup>177</sup>Lu-DOTATATE was measured using an ionization survey meter.</p><h3>Results</h3><p>The following relationships were observed between the radioactivity on <sup>111</sup>In-SRS and the 1 cm dose-equivalent rate on the day after administration of <sup>177</sup>Lu-DOTATATE: whole-body ROI: <i>y</i> = 0.16<i>x</i> + 5.01 (<i>r</i> = 0.56, <i>p</i> = 0.009), abdominal ROI: <i>y</i> = 0.27<i>x</i> + 5.13 (<i>r</i> = 0.63, <i>p</i> = 0.002). The regression equations indicate that patients cannot be released or discharged from the radiopharmaceutical room the day after <sup>177</sup>Lu-DOTATATE administration if the whole-body and abdominal ROI doses are greater than 81 and 48 MBq, respectively, on <sup>111</sup>In-SRS.</p><h3>Conclusions</h3><p>The amount of radioactivity accumulated on <sup>111</sup>In-SRS may be a predictor of release criteria for patients receiving <sup>177</sup>Lu-DOTATATE.</p></div>\",\"PeriodicalId\":8007,\"journal\":{\"name\":\"Annals of Nuclear Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12149-024-01962-0\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12149-024-01962-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Prediction of 1 cm dose-equivalent rate on the day after administration of 177Lu-DOTATATE from 111In-somatostatine receptor scintigraphy prior to treatment
Objective
When patients administered 177Lu-DOTATATE are released or discharged from rooms where radiopharmaceuticals are used, the time required for release or discharge varies across patients. This study investigated whether the amount of radioactivity accumulated on 111In-somatostatine receptor scintigraphy (111In-SRS) performed prior to treatment can predict the 1 cm dose-equivalent rate at a distance of 1 m from the patient on the day after 177Lu-DOTATATE administration.
Methods
Whole-body planar 111In-SRS images were acquired for 21 patients. Pixel values within whole-body and abdominal (35 × 25 cm) regions of interest (ROIs) were converted to radioactivity dose (MBq). The 1 cm dose-equivalent rate (µSv/h) at a distance of 1 m from the patient 18.3 ± 0.5 h after administration of 177Lu-DOTATATE was measured using an ionization survey meter.
Results
The following relationships were observed between the radioactivity on 111In-SRS and the 1 cm dose-equivalent rate on the day after administration of 177Lu-DOTATATE: whole-body ROI: y = 0.16x + 5.01 (r = 0.56, p = 0.009), abdominal ROI: y = 0.27x + 5.13 (r = 0.63, p = 0.002). The regression equations indicate that patients cannot be released or discharged from the radiopharmaceutical room the day after 177Lu-DOTATATE administration if the whole-body and abdominal ROI doses are greater than 81 and 48 MBq, respectively, on 111In-SRS.
Conclusions
The amount of radioactivity accumulated on 111In-SRS may be a predictor of release criteria for patients receiving 177Lu-DOTATATE.
期刊介绍：
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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