痴呆症对结直肠癌患者的影响:美国人群队列研究》。

Thanathip Suenghataiphorn, Narathorn Kulthamrongsri, Pojsakorn Danpanichkul, Sakditad Saowapa, Natchaya Polpichai, Jerapas Thongpiya
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引用次数: 0

摘要

背景/目的:结肠癌的各种社会经济和种族差异已得到充分证实。然而,痴呆症是导致老年人死亡的一个日益严重的原因,但其与结肠癌的关系仍未得到研究。我们旨在了解这两种疾病在老年人群中的关联:我们利用 2020 年全国住院病人抽样调查了通过 ICD-10 CM 编码识别的结直肠癌入院记录。我们根据是否患有痴呆症对记录进行了划分。使用多变量逻辑和线性回归模型确定了预定结果的调整几率比(aORs),并对合并症进行了调整。评估的主要结果是住院病人死亡率,次要结果包括其他住院并发症:我们确定了 33335 名年龄超过 60 岁的住院患者。平均年龄为 75.2 岁,男性占 50.4%。在利用倾向得分匹配调整患者和医院因素的多变量逻辑和线性回归调查模型中,痴呆症的存在与较低的住院患者死亡率相关(aOR 0.49,95% 置信区间 [CI] [0.26,0.92],p=0.03)、较低的住院费用(β系数-2,823,95% CI [-5,266,-440],p=0.02)、较低的急性呼吸衰竭几率(aOR 0.54,p=0.01)、较低的机械通气使用率(aOR 0.26,p结论:在住院治疗的结直肠癌患者中,痴呆症的存在与较低的住院死亡率风险及其他临床结果相关。应探讨这种关系背后的病因,以了解这种反向关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Dementia in Colorectal Cancer Patients: United States Population-Based Cohort Study.

Background/aims: Various socioeconomic and racial disparities are well-documented for colon cancer. However, the association of dementia, which is a growing cause of mortality in the elderly, remains unexplored. We aim to understand the association between these two conditions, in the elderly population group.

Methods: We utilized the 2020 National Inpatient Sample to investigate records admitted for colorectal cancer identified through ICD-10 CM codes. We divided records by the presence of dementia. Adjusted odds ratios (aORs) for predefined outcomes were determined using multivariable logistic and linear regression models, adjusting for comorbidities. The primary outcome assessed was inpatient mortality, while secondary outcomes include other inpatient complications.

Results: We identified 33,335 hospitalizations with ages more than 60. The mean age was 75.2 and males constituted 50.4%. In a survey multivariable logistic and linear regression model adjusting for patient and hospital factors, utilizing propensity score matching, the presence of dementia is associated with lower inpatient mortality (aOR 0.49, 95% confidence interval [CI] [0.26, 0.92], p=0.03), lower hospitalization costs (beta coefficient -2,823, 95% CI [-5,266, -440], p=0.02), lower odds of acute respiratory failure (aOR 0.54, p=0.01), lower mechanical ventilation usage (aOR 0.26, p<0.01) but higher odds of mental status change (aOR 1.97, 95% CI [1.37, 2.84], p<0.01).

Conclusions: The presence of dementia is associated with a lower risk of inpatient mortality, and other clinical outcomes, in colorectal cancer cases admitted for hospitalization. Etiologies behind this relationship should be explored to understand this inverse relationship.

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