Jonathon R Howlett, Heekyeong Park, Martin P Paulus
{"title":"作为创伤后应激障碍标志的感觉运动反馈控制功能障碍","authors":"Jonathon R Howlett, Heekyeong Park, Martin P Paulus","doi":"10.1016/j.bpsc.2024.07.010","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Posttraumatic stress disorder (PTSD) is characterized not only by its direct association with traumatic events but also by a potential deficit in inhibitory control across emotional, cognitive, and sensorimotor domains. Recent research has shown that a continuous sensorimotor feedback control task, the rapid assessment of motor processing paradigm, can yield reliable measures of individual sensorimotor control performance. This study used this paradigm to investigate control deficits in PTSD compared with both a healthy volunteer group and a non-PTSD psychiatric comparison group.</p><p><strong>Methods: </strong>We examined control processing using the rapid assessment of motor processing paradigm in a sample of 40 individuals with PTSD, matched groups of 40 individuals with mood and anxiety complaints, and 40 healthy control participants. We estimated K<sub>p</sub> (drive) and K<sub>d</sub> (damping) parameters using a proportional-derivative control modeling approach.</p><p><strong>Results: </strong>The K<sub>p</sub> parameter was lower in the PTSD group than in the healthy control (Cohen's d = 0.86) and mood and anxiety (Cohen's d = 0.63) groups. After controlling for color-word inhibition, K<sub>p</sub> remained lower in the PTSD group than in the healthy control (Cohen's d = 0.79) and mood and anxiety (Cohen's d = 0.62) groups. Mediation analysis showed that K<sub>d</sub> significantly mediated the relationship between PTSD and control deficits in the K<sub>p</sub> parameter, with 96% of the effect being mediated by K<sub>d</sub>.</p><p><strong>Conclusions: </strong>These findings underscore the potential of using dynamic control paradigms to elucidate the control dysfunctions in PTSD and suggest that different psychiatric conditions may distinctly influence subcomponents of sensorimotor control.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. 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This study used this paradigm to investigate control deficits in PTSD compared with both a healthy volunteer group and a non-PTSD psychiatric comparison group.</p><p><strong>Methods: </strong>We examined control processing using the rapid assessment of motor processing paradigm in a sample of 40 individuals with PTSD, matched groups of 40 individuals with mood and anxiety complaints, and 40 healthy control participants. We estimated K<sub>p</sub> (drive) and K<sub>d</sub> (damping) parameters using a proportional-derivative control modeling approach.</p><p><strong>Results: </strong>The K<sub>p</sub> parameter was lower in the PTSD group than in the healthy control (Cohen's d = 0.86) and mood and anxiety (Cohen's d = 0.63) groups. After controlling for color-word inhibition, K<sub>p</sub> remained lower in the PTSD group than in the healthy control (Cohen's d = 0.79) and mood and anxiety (Cohen's d = 0.62) groups. 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引用次数: 0
摘要
背景:创伤后应激障碍(PTSD创伤后应激障碍(PTSD)的特点不仅在于它与创伤事件的直接联系,还在于它在情绪、认知和感觉运动领域的抑制控制方面可能存在缺陷。最近的研究表明,一种连续的感觉运动反馈控制任务--运动处理快速评估(RAMP)范式--可以对个体的感觉运动控制表现进行可靠的测量。本研究利用该范式调查了创伤后应激障碍患者相对于健康志愿者和非创伤后应激障碍精神疾病对比组的控制缺陷:方法:我们使用 RAMP 范式对 40 名创伤后应激障碍患者以及 40 名情绪和焦虑(MA)症状患者和 40 名健康对照组(HC)进行了控制处理研究。我们使用比例-衍生(PD)控制模型方法估算了Kp(驱动)和Kd(阻尼)参数:结果:与 HC 组(Cohen's d = 0.86)和 MA 组(Cohen's d = 0.63)相比,创伤后应激障碍组的 Kp 参数较低。在对颜色词抑制进行控制后,创伤后应激障碍组的 Kp 仍低于 HC 组(Cohen's d = 0.79)和 MA 组(Cohen's d = 0.62)。中介分析表明,Kd对创伤后应激障碍与Kp参数控制缺陷之间的关系有明显的中介作用,96%的影响由Kd中介:这些发现强调了使用动态控制范式来阐明创伤后应激障碍中的控制功能障碍的潜力,并表明不同的精神疾病可能会对感觉运动控制的子组件产生不同的影响。
Sensorimotor Feedback Control Dysfunction as a Marker of Posttraumatic Stress Disorder.
Background: Posttraumatic stress disorder (PTSD) is characterized not only by its direct association with traumatic events but also by a potential deficit in inhibitory control across emotional, cognitive, and sensorimotor domains. Recent research has shown that a continuous sensorimotor feedback control task, the rapid assessment of motor processing paradigm, can yield reliable measures of individual sensorimotor control performance. This study used this paradigm to investigate control deficits in PTSD compared with both a healthy volunteer group and a non-PTSD psychiatric comparison group.
Methods: We examined control processing using the rapid assessment of motor processing paradigm in a sample of 40 individuals with PTSD, matched groups of 40 individuals with mood and anxiety complaints, and 40 healthy control participants. We estimated Kp (drive) and Kd (damping) parameters using a proportional-derivative control modeling approach.
Results: The Kp parameter was lower in the PTSD group than in the healthy control (Cohen's d = 0.86) and mood and anxiety (Cohen's d = 0.63) groups. After controlling for color-word inhibition, Kp remained lower in the PTSD group than in the healthy control (Cohen's d = 0.79) and mood and anxiety (Cohen's d = 0.62) groups. Mediation analysis showed that Kd significantly mediated the relationship between PTSD and control deficits in the Kp parameter, with 96% of the effect being mediated by Kd.
Conclusions: These findings underscore the potential of using dynamic control paradigms to elucidate the control dysfunctions in PTSD and suggest that different psychiatric conditions may distinctly influence subcomponents of sensorimotor control.