小鼠自愿饮酒和禁酒诱发负性情绪模型的性别差异

IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Amanda L. Salazar, Samuel W. Centanni
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引用次数: 0

摘要

酒精使用障碍(AUD)是一个日益严重的世界性问题,给健康和经济造成了巨大负担。尽管 AUD 影响着各种背景和人口结构的人群,但越来越多的证据表明,在饮酒模式和 AUD 引起的负面情绪或过度情绪方面存在着明显的性别差异。女性的问题性饮酒率明显上升,女性在戒酒时面临更严重的负面情绪后果,如合并焦虑或情绪障碍的风险增加,抑郁症状更严重。因此,为了更好地了解性别作为饮酒和戒酒诱发负面情绪的一个生物变量,近年来积累了大量使用酒精(乙醇)消费或然法的临床前文献。小鼠被广泛用于建立饮酒模型,因为它们有利于遗传操作策略,而且许多品系的小鼠会自愿饮酒。然而,这些小鼠研究的性别特异性结果并不一致。因此,本综述旨在总结小鼠与 AUD 相关的或然乙醇饮酒和禁欲诱导的负性情绪的性别差异的现有知识。本综述介绍了各种或然性小鼠饮酒模型和基于负性情绪的行为范式,随后在性别差异的背景下进行了讨论,以显示在 AUD 的小鼠临床前研究中越来越多的性别特异性迹象。通过这篇综述,我们希望为今后有关 AUD 临床前小鼠模型中潜在性别差异的研究提供信息,并提供越来越多的证据支持在今后的研究中更广泛地纳入临床前女性受试者的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex Differences in Mouse Models of Voluntary Alcohol Drinking and Abstinence-Induced Negative Emotion

Alcohol Use Disorder (AUD) is a growing problem worldwide, causing an incredible burden on health and the economy. Though AUD impacts people of all backgrounds and demographics, increasing evidence has suggested robust sex differences in alcohol drinking patterns and AUD-induced negative emotionality or hyperkatifeia. Rates of problematic drinking have significantly risen among women, and women face more severe negative emotional consequences in abstinence such as increased risk of comorbidity with an anxiety or mood disorder and more severe symptoms of depression. As such, a bevy of preclinical literature using contingent methods of alcohol (ethanol) consumption has amassed in recent years to better understand sex as a biological variable in alcohol drinking and abstinence-induced negative emotionality. Mice are widely used to model alcohol drinking, as they are conducive to genetic manipulation strategies, and many strains will voluntarily consume alcohol. Sex-specific results from these mouse studies, however, have been inconsistent. Therefore, this review aims to summarize the current knowledge on sex differences in AUD-related contingent ethanol drinking and abstinence-induced negative emotionality in mice. Various contingent mouse drinking models and negative emotional-based behavioral paradigms are introduced and subsequently discussed in the context of sex differences to show increasing indications of sex specificity in mouse preclinical studies of AUD. With this review, we hope to inform future research on potential sex differences in preclinical mouse models of AUD and provide mounting evidence supporting the need for more widespread inclusion of preclinical female subjects in future studies.

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来源期刊
Alcohol
Alcohol 医学-毒理学
CiteScore
4.60
自引率
4.30%
发文量
74
审稿时长
15.6 weeks
期刊介绍: Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.
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