环境污染物对自闭症和其他神经发育障碍风险的影响:病例对照研究的系统回顾。

IF 7.5 1区 医学 Q1 BEHAVIORAL SCIENCES
A.M. Tartaglione , L. Camoni , G. Calamandrei, F. Chiarotti, A. Venerosi
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引用次数: 0

摘要

早期暴露于环境污染物(如金属、杀虫剂和空气污染物)是神经发育障碍(NDD)(包括自闭症谱系障碍(ASD))的一个风险因素。我们的系统性综述旨在选择和总结近期的病例对照研究,这些研究探讨了产前和产后早期暴露于环境污染物与 NDD 之间的关系。我们检索了五个数据库(Web of Science、PubMed、Embase、Scopus、Ovid),筛选了 2,261 条记录,纳入了 24 项符合条件的病例对照研究。对至少三项研究的子组进行了元分析,这些子组的研究结果和暴露情况相同。本次文献综述的一个值得注意的发现是,某些金属的暴露与 ASD 风险之间存在非线性或非单调的剂量-反应关系。荟萃分析表明,婴儿出生后第一年接触特定物质(PM)10 与 ASD 风险之间存在显著关联。总体而言,我们的系统综述所包括的研究表明,出生后头三年内暴露于几种污染物与罹患非传染性疾病的风险有显著关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The contribution of environmental pollutants to the risk of autism and other neurodevelopmental disorders: A systematic review of case-control studies

Exposure to environmental pollutants, such as metals, pesticides, and air pollutants during early life, is a risk factor for neurodevelopmental disorders (NDDs), including Autism Spectrum Disorder (ASD). Our systematic review aimed to select and summarize more recent case-control studies that examined the association between prenatal and early postnatal exposure to environmental pollutants and NDDs. We searched five databases (Web of Science, PubMed, Embase, Scopus, Ovid), screened 2261 records, and included 24 eligible case-control studies. Meta-analyses were conducted on subgroups of at least three studies that shared both the outcome and the exposure. A noteworthy discovery from this literature review is the existence of non-linear or non-monotonic dose-response relationships between the exposure to certain metals and the risk of ASD. The meta-analysis revealed a significant association between exposure to particular matter (PM)10 during the first year of life and the risk of ASD. Overall, studies included in our systematic review indicate that exposure to several pollutants within the first three years of life was significantly associated with the risk of NDDs.

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来源期刊
CiteScore
14.20
自引率
3.70%
发文量
466
审稿时长
6 months
期刊介绍: The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.
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